2. Immunology/Inflammation
  3. Interleukin Related
  4. Inbakicept

Inbakicept 

目录号: HY-P99661 纯度: 98.95%
COA

摩尔计算器

Inbakicept 是一种二聚体人 IL-15 受体 α (IL-15 Ra) sushi 结构域/人 IgG1 Fc 融合蛋白，是一种 IL-15 超级激动剂复合物。 Inbakicept 能够与 IL-15 抗体 Nogapendekin alfa 以 1:2 的比例形成复合物 N-803 (Nogapendekin alfa inbakicept)。N-803 能够模拟 IL-15 的功能，并放大抗 CD20 mAb 介导的 NK 细胞反应和抗体依赖性细胞毒性 (ADCC)。N-803 还可以增加细胞中的脱颗粒和 IFNγ 的产生。

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CAS No. : 2135939-52-3

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规格 价格 是否有货 数量
1 mg ￥7500
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Inbakicept 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells[1].

种属

Human
IC50 & Target[1]

IL-15Rα

 

体外研究
(In Vitro)

Inbakicept (0.01-1 nM；20 小时) 增强人 NK 细胞的细胞毒性并增加细胞毒性效应分子的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Inbakicept 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Daudi, Raji, CD19+ FL cells
Concentration: 0.01 nM, 0.1 nM, and 1 nM
Incubation Time: 20 hours
Result: Increased the human NK cell cytotoxicity on Daudi, Raji, CD19+ FL cells.
体内研究
(In Vivo)

Inbakicept (0.2 mg/kg；静脉注射；每周两次，持续 2 周) 在小鼠模型中增强利妥昔单抗对致死性 Daudi 淋巴瘤攻击的保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with Daudi models[1]
Dosage: 0.02 mg/kg, 0.05 mg/kg, 0.1 mg/kg, and 0.2 mg/kg
Administration: Intravenous injection; twice weekly, for 2 weeks
Result: Enhanced rituximab-directed control of Raji lymphoma challenge.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [IL15RA (interleukin 15 receptor subunit alpha, CD215, IL-15RA)]2-IGHG1 Fc (Fragment constant)
Biological Activity
  • Immobilized Human IL-15 Protein can bind Inbakicept. The EC50 for this effect is 50.78 ng/mL.
纯度 & 产品资料
参考文献

Inbakicept 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inbakicept2135939-52-3Interleukin RelatedILInhibitorinhibitorinhibit

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目录号：
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