2. Immunology/Inflammation
  3. Nuclear Factor of activated T Cells (NFAT)
  4. INCA-6

INCA-6  (Synonyms: Triptycene-1,4-quinone)

目录号: HY-108544 纯度: 98.85%
COA 产品使用指南

摩尔计算器

INCA-6 (Triptycene-1,4-quinone) 是一种细胞渗透性 NFAT 抑制剂。INCA-6 特异性阻断 NFAT底物靶向钙调神经磷酸酶位点，是 calcineurin (CN)-NFAT 信号传导的有效抑制剂。

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INCA-6 Chemical Structure

INCA-6 Chemical Structure

CAS No. : 3519-82-2

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5 mg ￥1700
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10 mg ￥2700
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25 mg ￥5400
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Customer Review

INCA-6 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the  calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling[1][2][3].

体外研究
(In Vitro)

INCA-6 (5 μM; for 24-hour) prevents transient outward K+ current (Ito) downregulation in 3-Hz cells[1].
Pre-treatment of BV-2 cells with INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in BV-2 cells. INCA-6 also inhibits ATP-induced CXCL2 expression in rat primary microglia[2]. 
INCA-6 (5 μM) reduces SERCA2 transcript levels as well as protein expression, in the absence or in the presence of  thapsigargin (TG)[3].
INCA-6 (1.0 and 2.5 μM; 24 hours ) treatment significantly decreases both VEGF and serum-induced human retinal microvascular endothelial cells (HRMEC) proliferation, but does not affect baseline proliferation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

INCA-6 相关抗体:

Cell Proliferation Assay[4]

Cell Line: Human retinal microvascular endothelial cells
Concentration: 0.5, 1.0, or 2.5 μM
Incubation Time: 24 hours
Result: Significantly inhibited VEGF-induced proliferation at 1.0 and 2.5 μM concentrations.
体内研究
(In Vivo)

INCA-6 (5.0, or 25.0 μM) treatment significantly reduces pathologic neovascularization in oxygen-induced retinopathy (OIR)[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats bearing OIR model[4]
Dosage: 2.5, 5.0, or 25.0 μM
Administration: Intravitreal injection on days 14(0) and 14(3)
Result: Decreased the severity of OIR in a dose dependent manner. Significant inhibition was seen at 5.0 and 25.0 μM concentrations.
分子量

284.31

Formula

C20H12O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2.86 mg/mL (10.06 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5173 mL 17.5864 mL 35.1729 mL
5 mM 0.7035 mL 3.5173 mL 7.0346 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

INCA-6 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5173 mL 17.5864 mL 35.1729 mL 87.9322 mL
5 mM 0.7035 mL 3.5173 mL 7.0346 mL 17.5864 mL
10 mM 0.3517 mL 1.7586 mL 3.5173 mL 8.7932 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INCA-63519-82-2Triptycene-1,4-quinoneINCA6INCA 6Nuclear Factor of activated T Cells (NFAT)NFATretinalmicrovascularendothelialoxygen-inducedretinopathytranscriptionfactorsneovascularizationInhibitorinhibitorinhibit

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