2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CCR HIV
  4. INCB9471

INCB9471 是一种有效的、选择性和具有口服活性的 CCR5 拮抗剂。INCB9471 具有抗 HIV-1 活性。

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INCB9471 Chemical Structure

INCB9471 Chemical Structure

CAS No. : 869769-98-2

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规格 是否有货
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Other Forms of INCB9471:

INCB9471 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

查看所有亚型
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

查看 HIV 亚型特异性产品:

查看所有亚型
HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

INCB9471 is a potent, selective and orally active CCR5 antagonist. INCB9471 shows anti-HIV-1 activity[1][2].

IC50 & Target[1][2]

CCR5

 

HIV-1

 

体外研究
(In Vitro)

INCB9471 (0-1 µM) 抑制 MIP-1 诱导的 rhIL-10 处理的人类单核细胞趋化性，IC50 值为 4.8 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

INCB9471 相关抗体:
体内研究
(In Vivo)

药代动力学[2].

rats dogs
i.v. dose iv/po (mg/kg) 1/20 1/20
CL (L/h/kg) 0.62 0.2
Vdss (L/h) 4.1 3.8
T1/2 (h) 6 11
AUC (nM h) 2898 7854
p.o. Tmax (h) 3 0.5
Cmax(ng/mL) 4071 14007
C24h (nM) 1088
T1/2 (h) 12 17
AUC (nM h) 55160 149779
F (%) 100 95

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

559.67

Formula

C30H40F3N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

INCB9471 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INCB9471869769-98-2INCB 9471INCB-9471CCRHIVCC chemokine receptorHuman immunodeficiency virusorally activeanti-HIV-1 activitymonocytesInhibitorinhibitorinhibit

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产品名称：
INCB9471
目录号：
HY-14230
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