2. Immunology/Inflammation
  3. IRAK
  4. IRAK4-IN-20

IRAK4-IN-20 (Compound BAY-1834845) 是一种具有口服活性的 IRAK4 抑制剂， IC50 为 3.55 nM。 IRAK4-IN-20 可用于急性呼吸窘迫综合征 (ARDS) 的研究。

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IRAK4-IN-20 Chemical Structure

IRAK4-IN-20 Chemical Structure

CAS No. : 1931994-80-7

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规格 价格 是否有货 数量
1 mg ￥2208
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Customer Review

IRAK4-IN-20 相关抗体

Top Publications Citing Use of Products

查看 IRAK 亚型特异性产品:

查看所有亚型
IRAK1 IRAK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. IRAK4-IN-20 can be used for acute respiratory distress syndrome (ARDS) research[1].

IC50 & Target

IRAK4

3.55 nM (IC50)

体外研究
(In Vitro)

IRAK4-IN-20 (Compound BAY-1834845) (500 nM, 20 h) decreases inflammatory cytokines secretion effectively in an in vitro treatment of LPS stimulated human peripheral blood mononuclear cells (PBMC)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IRAK4-IN-20 相关抗体:
体内研究
(In Vivo)

IRAK4-IN-20 (Compound BAY-1834845) (150 mg/kg; p.o.; once or twice) effectively prevents acute respiratory distress syndrome in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice (aged 6–7 weeks), LPS-induced ARDS mouse model[1]
Dosage: 150 mg/kg
Administration: Oral administration, 30 min before LPS modeling or twice 4 h and 12 h after LPS modeling
Result: Remarkably decreased inflammatory cells infiltrating lung tissue and neutrophil count in BALF.
Effectively reduced the numbers of total T cells, monocyte, and macrophages.
Largely preserved the signatures of naïve lymphocytes and stromal cells such as endothelial cells, chondrocytes, and smooth muscle cells.
Regulated inflammation and innate immunity genes more efficiently than Dexamethasone (HY-14648).
分子量

450.45

Formula

C22H25F3N4O3
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (277.50 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2200 mL 11.1000 mL 22.2000 mL
5 mM 0.4440 mL 2.2200 mL 4.4400 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

IRAK4-IN-20 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2200 mL 11.1000 mL 22.2000 mL 55.5001 mL
5 mM 0.4440 mL 2.2200 mL 4.4400 mL 11.1000 mL
10 mM 0.2220 mL 1.1100 mL 2.2200 mL 5.5500 mL
15 mM 0.1480 mL 0.7400 mL 1.4800 mL 3.7000 mL
20 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7750 mL
25 mM 0.0888 mL 0.4440 mL 0.8880 mL 2.2200 mL
30 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8500 mL
40 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3875 mL
50 mM 0.0444 mL 0.2220 mL 0.4440 mL 1.1100 mL
60 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9250 mL
80 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.6938 mL
100 mM 0.0222 mL 0.1110 mL 0.2220 mL 0.5550 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-201931994-80-7IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseacute respiratory distress syndromeARDSInhibitorinhibitorinhibit

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产品名称：
IRAK4-IN-20
目录号：
HY-150735
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