2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Adrenergic Receptor Endogenous Metabolite
  4. Isoprenaline

Isoprenaline 是一种非选择性的 β-肾上腺素受体激动剂，具有口服活性。Isoprenaline 具有强效的外周血管扩张、支气管扩张和心脏刺激活性。Isoprenaline 可用于心动过缓和支气管哮喘的研究。

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Isoprenaline Chemical Structure

Isoprenaline Chemical Structure

CAS No. : 7683-59-2

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Isoprenaline 的其他形式现货产品:

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Isoprenaline 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 51 篇科研文献

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RT-PCR

    Isoprenaline purchased from MCE. Usage Cited in: Cell Mol Immunol. 2023 Jan 5.  [Abstract]

    Isoprenaline hydrochloride (ISO; 10 μM; 6 h), markedly inhibits SeV- or HSV-1-induced transcription of the IFNB1 and CXCL10 genes in THP1 cells.

    Isoprenaline purchased from MCE. Usage Cited in: Cell Mol Immunol. 2023 Jan 5.  [Abstract]

    Isoprenaline hydrochloride (ISO; 10 μM; 0, 3, 6, 9 h) inhibits the phosphorylation of MITAS366, IRF3S386 and STAT1Y701 induced by HSV-1, HSV-2 and HCMV, as well as the phosphorylation of IRF3S386 and STAT1Y701 induced by SeV, EMCV and VSV, in THP1 cells.

    Isoprenaline purchased from MCE. Usage Cited in: Food Chem Toxicol. 2023 Feb 17;113670.  [Abstract]

    Isoprenaline hydrochloride (ISO; 10 μM; 6 h) pretreatment markedly restores the ATGL and HSL expressions decreased by 1,3-dichloro-2-propanol (1,3-DCP; 100 μM; 6 h) in HepG2 cells.

    Isoprenaline purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2019 Apr 25;38(1):174.   [Abstract]

    EHD1 stabilizes β2AR. A549 cells are incubated in serum-free 1640 medium for 16 h and then treated with ISO (10 μM) for the indicated times in the presence of cycloheximide (CHX, 20 μg/mL). The cell lysates are analyzed by Western blot.

    Isoprenaline purchased from MCE. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1373-1385.  [Abstract]

    NRCMs are pre-incubated with PCA (50, 100, and 200 μM) for 1 h followed by 10 μM Isoproterenol (ISO) treatment. Cell surface area is measured by rhodamine-phalloidin staining. The expression of β-MHC is detected by Western blot.

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    α adrenergic receptor β adrenergic receptor

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma[1][2][3][4][5][6].

    体外研究
    (In Vitro)

    Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells[1].
    Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity[2].
    Isoprenaline (5 nM and 10 μM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO)[3].
    Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged[4].
    Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current[5].
    Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Isoprenaline 相关抗体:
    体内研究
    (In Vivo)

    Isoprenaline (oral, 0.27-0. 64 μg/kg) is extensively metabolizes by a relatively small number of reactions in dogs[6].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Dogs[1]
    Dosage: 0.27-0. 64 μg/kg
    Administration: oral
    Result: Excreted largely unchanged in urine, only one-third of the radioactivity in urine was in the form of the O-methyl metabolite.
    Showed plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine.
    . Showed heart rate returned to base-line values when high plasma concentrations.
    Clinical Trial
    分子量

    211.26

    Formula

    C11H17NO3
    CAS 号
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Isoprenaline 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Isoprenaline7683-59-2Adrenergic ReceptorEndogenous MetaboliteBeta Receptorperipheral vasodilatorbronchodilatorcardiac stimulating activitiesInhibitorinhibitorinhibit

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