2. Anti-infection
  3. Bacterial Antibiotic
  4. Iturin A-2

Iturin A-2 是一种可在 B. subtilis 被发现的环状脂肽，对植物病原真菌 P. expansum 具有抑制活性 (MIC 为 8 µg/纸片)。Iturin A-2 对 MCF-7 和 BT474 乳腺癌细胞以及 HeLa 宫颈癌细胞具有细胞毒性，IC50 分别为 66.81, 95.04 和 77.5 µg/mL。在温室研究中，100 和 300 mg/kg 浓度的 Iturin A-2 可以减少由 B. maydis 引起的南方玉米叶斑病斑块面积，并且在田间研究中，300 和 500 mg/kg 浓度可以减少南方玉米叶斑病的发生率。Iturin A-2 (12.5 µg/mL) 还能抑制孤立的受精海星卵的细胞分裂，但不影响核分裂。

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Iturin A-2 Chemical Structure

Iturin A-2 Chemical Structure

CAS No. : 83785-07-3

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Iturin A-2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC50 values of 66.81, 95.04, and 77.5 µg/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 µg/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs[1][2][3][4].

分子量

1043.17

Formula

C48H74N12O14
CAS 号
Sequence

Cyclo({d-Asn}-Gln-Pro-{d-Asn}-Ser-{(3R)-3-aminotetradecanoic acid}-Asn-{d-Tyr})
Sequence Shortening

Cyclo({d-Asn}-QP-{d-Asn}-S-{(3R)-3-aminotetradecanoic acid}-N-{d-Tyr})
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Iturin A-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iturin A-283785-07-3Iturin A2Iturin A 2BacterialAntibioticInhibitorinhibitorinhibit

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目录号：
HY-P10785
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