2. Apoptosis JAK/STAT Signaling Stem Cell/Wnt Epigenetics Protein Tyrosine Kinase/RTK
  3. Apoptosis JAK
  4. JAK-2/3-IN-3

JAK-2/3-IN-3 (化合物 ST4j) 是一种强效的 JAK2/3 抑制剂，其对 JAK2 和 JAK3 的 IC50 值分别为 13.00 和 14.86 nM。JAK-2/3-IN-3 以剂量和时间依赖的方式抑制 JAK2 的自磷酸化并诱导细胞凋亡。JAK-2/3-IN-3 可用于淋巴衍生疾病和白血病的研究。

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JAK-2/3-IN-3 Chemical Structure

JAK-2/3-IN-3 Chemical Structure

CAS No. : 2242031-31-6

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JAK-2/3-IN-3 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JAK-2-/3-IN-3 (compound ST4j) is a potent JAK2/3 inhibitor with IC50s of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. JAK-2-/3-IN-3 inhibits autophosphorylation of JAK2 and induces apoptosis in a dose- and time-dependent manner. JAK-2-/3-IN-3 can be used in studies of lymph derived diseases and leukemia[1].

IC50 & Target[1]

JAK2

13.00 nM (IC50)

JAK3

14.86 nM (IC50)

体外研究
(In Vitro)

JAK-2/3-IN-3 (0-100 μM; 72 h) specifically inhibits human erythroleukemia cells with low toxicity to the normal cells[1].
JAK-2/3-IN-3 inhibits human erythroleukemia TF1 cell growth via the JAK2/STAT5 signaling pathway[1].
JAK-2/3-IN-3 (15.53 μM; 24, 48, 72 h) induces cytotoxicity via apoptosis in a time-dependent manner in TF1 cells[1].
JAK-2/3-IN-3 (IC25, IC50, IC75; 24 h) induces cytotoxicity via apoptosis in a dose-dependent manner in TF1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JAK-2/3-IN-3 相关抗体:

Apoptosis Analysis[1]

Cell Line: TF1 cells
Concentration: 15.53 μM
Incubation Time: 24, 48, 72 h
Result: Increased cells apoptotic by ∼20%, ∼40% and ∼70%, after 24-, 48- and 72-h incubations, respectively.
Increased cells apoptotic by ∼15%, 20%, and 30% with concentration of IC25, IC50 and IC75, respectively.

Cell Cytotoxicity Assay[1]

Cell Line: TF1, HEL, Vero and HepG2 cells
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Inhibited growth of TF1 and HEL cells, with IC50s of 15.53 and 17.90 μM.
Showed low toxic to normal Vero cells and HepG2 cells (IC50 of >100 μM in Vero cells and of >50 μM in HepG2 cells).
分子量

325.15

Formula

C13H10Cl2N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JAK-2/3-IN-3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK-2/3-IN-32242031-31-6ApoptosisJAKJanus kinaseTF1HELVeroHepG2lymph derived diseasesleukemiacancerInhibitorinhibitorinhibit

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