2. Metabolic Enzyme/Protease
  3. Amine N-methyltransferase
  4. JBSNF-000028 hydrochloride

JBSNF-000028 hydrochloride 

目录号: HY-151500B 纯度: 95.83%
COA 产品使用指南 技术支持

JBSNF-000028 hydrochloride 是一种具有口服活性的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂，对人 NNMT (hNNMT)、猴 NNMT (mkNNMT) 和小鼠 NNMT (mNNMT) 的 IC50 分别为 0.033 μM、0.19 μM 和 0.21 μM。

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JBSNF-000028 hydrochloride Chemical Structure

JBSNF-000028 hydrochloride Chemical Structure

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥4026
In-stock
1 mg ￥1636
In-stock
5 mg ￥3600
In-stock
10 mg ￥5700
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of JBSNF-000028 hydrochloride:

JBSNF-000028 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JBSNF-000028 hydrochloride is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 hydrochloride can be used for the research of metabolic disorders[1].

IC50 & Target

IC50: 0.033 μM (hNNMT), 0.19 μM (mkNNMT), 0.21 μM (mNNMT)[1]
体外研究
(In Vitro)

JBSNF-000028 hydrochloride (24 h) inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells[1].
JBSNF-000028 hydrochloride (10-100 μM; 72 h) has no cytotoxicity against HepG2 cells[1].
JBSNF-000028 hydrochloride binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from central domain)[1].
JBSNF-000028 hydrochloride is inactive against a broad panel of targets related to metabolism and safety[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JBSNF-000028 hydrochloride 相关抗体:
体内研究
(In Vivo)

JBSNF-000028 hydrochloride (50 mg/kg; p.o.; twice daily for 27 days) improves glucose and lipid handling in mice with diet-induced obesity (DIO)[1].
JBSNF-000028 hydrochloride (50 mg/kg; p.o.; twice daily for 4 weeks) improves glucose tolerance in NNMT knockout mice with diet-induced obesity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

223.70

Formula

C11H14ClN3
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 16.67 mg/mL (74.52 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.4703 mL 22.3514 mL 44.7027 mL
5 mM 0.8941 mL 4.4703 mL 8.9405 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

JBSNF-000028 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4703 mL 22.3514 mL 44.7027 mL 111.7568 mL
5 mM 0.8941 mL 4.4703 mL 8.9405 mL 22.3514 mL
10 mM 0.4470 mL 2.2351 mL 4.4703 mL 11.1757 mL
15 mM 0.2980 mL 1.4901 mL 2.9802 mL 7.4505 mL
20 mM 0.2235 mL 1.1176 mL 2.2351 mL 5.5878 mL
25 mM 0.1788 mL 0.8941 mL 1.7881 mL 4.4703 mL
30 mM 0.1490 mL 0.7450 mL 1.4901 mL 3.7252 mL
40 mM 0.1118 mL 0.5588 mL 1.1176 mL 2.7939 mL
50 mM 0.0894 mL 0.4470 mL 0.8941 mL 2.2351 mL
60 mM 0.0745 mL 0.3725 mL 0.7450 mL 1.8626 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBSNF-000028JBSNF000028JBSNF 000028Amine N-methyltransferasetype 2 diabetesliver diseasesnicotinamide N-methyltransferaseNNMTInhibitorinhibitorinhibit

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产品名称：
JBSNF-000028 hydrochloride
目录号：
HY-151500B
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