2. Epigenetics
  3. Histone Demethylase
  4. JMJD7-IN-1

JMJD7-IN-1 是一种有效的 JMJD7 抑制剂，IC50 值为 6.62 μM。JMJD7-IN-1 对表达高水平 JMJD7 的细胞显示出良好的抑制活性。

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JMJD7-IN-1 Chemical Structure

JMJD7-IN-1 Chemical Structure

CAS No. : 311316-96-8

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥399
In-stock
5 mg ￥500
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10 mg ￥800
In-stock
25 mg ￥1700
In-stock
50 mg ￥2700
In-stock
100 mg ￥4300
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

JMJD7-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

查看所有亚型
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JMJD7-IN-1 is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7[1].

IC50 & Target

IC50: 6.62 μM (JMJD7)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BJ IC50
> 100 μM
Compound: 3
Cytotoxicity against human BJ cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human BJ cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
HeLa IC50
16.14 μM
Compound: 3
Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
Jurkat IC50
15.03 μM
Compound: 3
Cytotoxicity against human Jurkat cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
SH-SY5Y IC50
> 100 μM
Compound: 3
Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
SK-BR-3 IC50
13.26 μM
Compound: 3
Cytotoxicity against human SK-BR-3 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human SK-BR-3 cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
T47D IC50
9.4 μM
Compound: 3
Cytotoxicity against human T47D cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human T47D cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
体外研究
(In Vitro)

JMJD7-IN-1 (0.1-1000 μM) 剂量依赖性地抑制 JMJD7 的活性，IC50 为 6.62 μM[1]。
JMJD7 -IN-1 有效结合 JMJD7，IC50 为 3.80 μM[1]。
JMJD7-IN-1 (72 h) 抑制生长T-47d、SK-BR-3、Jurkat 和 Hela 细胞，IC50 分别为 9.40 μM、13.26 μM、15.03 μM 和 16.14 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JMJD7-IN-1 相关抗体:
分子量

363.15

Formula

C16H8Cl2N2O4
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 8.33 mg/mL (22.94 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7537 mL 13.7684 mL 27.5368 mL
5 mM 0.5507 mL 2.7537 mL 5.5074 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

JMJD7-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7537 mL 13.7684 mL 27.5368 mL 68.8421 mL
5 mM 0.5507 mL 2.7537 mL 5.5074 mL 13.7684 mL
10 mM 0.2754 mL 1.3768 mL 2.7537 mL 6.8842 mL
15 mM 0.1836 mL 0.9179 mL 1.8358 mL 4.5895 mL
20 mM 0.1377 mL 0.6884 mL 1.3768 mL 3.4421 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMJD7-IN-1311316-96-8Histone DemethylaseJMJD7cancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
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