1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 信号通路化合物库系列
  5. 甲基化化合物库
甲基化化合物库 - Methylation Compound Library

Cat. No.: HY-L203

甲基化是一种表观遗传修饰机制,甲基化涉及向 DNA、组蛋白等分子添加甲基基团,可在不改变 DNA 序列的情况下改变基因表达。这一过程由 DNA 甲基转移酶 (DNA methyltransferases, DNMTs) 和组蛋白甲基转移酶 (histone methyltransferases, HMTs) 等酶催化,并可被去甲基化酶逆转。 甲基化与去甲基化的平衡对于维持细胞功能和基因组稳定性至关重要。甲基化异常调节可能导致包括癌症、神经系统疾病和发展异常在内的多种疾病。深入理解甲基化代谢的分子机制对于开发与甲基化失调相关疾病的治疗策略至关重要。

MCE 收录了靶向甲基化酶/去甲基化酶的 259 个小分子化合物,该库对于研究甲基化代谢途径、探索其在疾病中的作用机制具有重要价值。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 甲基化化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,257 个产品以 10 mM 浓度提供,1 个产品以 2 mM 浓度提供,1 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
- +

Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情

活性描述 & 特点

Biological Activity

•   A unique collection of 259 methylation related compounds.

•   A useful tool for drug discovery in diseases such as cancer and epigenetics.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, bioactive, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 259 methylation related compounds supplied as pre-dissolved Solutions or Solid.
Solution: 257 compounds supplied in 10 mM solution, 1 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

* Container:

       留言给我们:

    Bulk Inquiry

    Inquiry Information

    产品名称:
    Methylation Compound Library
    目录号:
    HY-L203
    需求量: