2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12C inhibitor 65

KRAS G12C inhibitor 65 是一种有效的 KRASG12C 共价抑制剂，可将 KRASG12C 捕获在 GDP 结合状态。KRAS G12C inhibitor 65 对 KRAS 突变型非小细胞肺癌具有有效的抗肿瘤活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KRAS G12C inhibitor 65 Chemical Structure

KRAS G12C inhibitor 65 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

KRAS G12C inhibitor 65 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS G12C inhibitor 65 is a potent and covalent KRASG12C inhibitor that traps KRASG12C in the GDP-bound state. KRASG12C IN-1 exhibits potent antitumor activity against KRAS-mutant non-small cell lung cancer[1].

体外研究
(In Vitro)

KRAS G12C inhibitor 65 (compound 20a) (72 h) shows potent and selective antiproliferative activities against KRASG12C NSCLC cells, with IC50s of 0.5 μM against NCI-H358 cells and 1.30 μM against NCI-H23 cells, with 7- to 21-fold selectivity over KRASG12S and KRASWT cells[1].
KRAS G12C inhibitor 65 (0.5-8.0 μM; 6 h) decreases the phosphorylation of ERK and AKT in KRASG12C-mutant NCIH358 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS G12C inhibitor 65 相关抗体:

Western Blot Analysis[1]

Cell Line: NCI-H358 and NCI-H2228 cells
Concentration: 0.5, 1.0, 2.0, 4.0, 8.0 μM
Incubation Time: 6 hours
Result: Showed no impact on KRAS signaling in KRASWT NCI-H2228 cells.
The pERK level decreased 40%-90%, and the pAKT level was down-regulated by 30%-90% in NCI-H358 cells.
体内研究
(In Vivo)

KRAS G12C inhibitor 65 (compound 20a) (10-15 mg/kg; i.p. every 2 d for 21 d) inhibited tumor growth in H358 xenografts by suppressing KRASG12C signalling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c Nude mice were injected subcutaneously with NCI-H358 cells[1]
Dosage: 10, 15 mg/kg
Administration: I.p. every two days for 21 days
Result: Significantly inhibited tumor growth while the body weight of mice was not influenced.
分子量

410.27

Formula

C19H18Cl2FN3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS G12C inhibitor 65 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12C inhibitor 65RasGDPantitumorKRAS-mutantnon-small cell lung cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
KRAS G12C inhibitor 65
目录号：
HY-151999
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z