2. Anti-infection Apoptosis
  3. Antibiotic Bcl-2 Family Apoptosis
  4. KRN5500

KRN5500  (Synonyms: NSC 650426)

目录号: HY-13659
产品使用指南

摩尔计算器

KRN5500 (NSC 650426) 是一种具有抗肿瘤活性的 Spicamycin (HY-127130) 衍生物，也是一种核苷酸类型的抗生素。KRN5500 通过下调 Bcl-2 的表达诱导细胞凋亡 (apoptosis)。KRN5500 在小鼠的人源肿瘤异种移植模型中表现出显著的抑制效力。

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KRN5500 Chemical Structure

KRN5500 Chemical Structure

CAS No. : 151276-95-8

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KRN5500 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRN5500 (NSC 650426), a Spicamycin (HY-127130) derivative and a nucleoside-like antibiotic with anti-tumor activity. KRN5500 also induces apoptosis via the down-regulation of Bcl-2 expression. KRN5500 shows a significant efficacy in the human tumor xenograft model in mice[1][2].

IC50 & Target[1]

Bcl-2

 

体外研究
(In Vitro)

KRN5500 (10-160 ng/mL; 0-5 d) 有效抑制 NB4、NKM-1 和 HL-60 细胞的增殖和活力[1]。
KRN5500 (40 ng/mL, 160 ng/mL; 48 h) 诱导 NB4、HL-60 和 NKM-1 细胞凋亡[1]。
KRN5500 (40 ng /mL, 80 ng /mL; 36 h) 下调 NB4 细胞中 Bcl-2 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRN5500 相关抗体:

Cell Viability Assay[1]

Cell Line: NB4, HL-60, NKM-1, NOP-1 and Daudi cells
Concentration: 10 ng/mL, 20 ng/mL, 40 ng/mL, 80 ng/mL, 160 ng/mL
Incubation Time: 0, 1, 2, 3, 4, and 5 days or 72 h
Result: Completely inhibited cell proliferation and viability of NB4 and NKM-1 at about 80 ng/mL, of HL-60 at 160 ng/mL.
Inhibited cells viability of IC50s of 51.6 ng/mL, 89.7 ng/mL, 66.5 ng/mL, 277.0 ng/mL, 242.1 ng/mL, respectively.

Western Blot Analysis[1]

Cell Line: NB4 cells
Concentration: 40 ng/mL, 80 ng/mL
Incubation Time: 36 h
Result: Reduced the Bcl-2 expression without affecting Bcl-xL and Bax expression.
体内研究
(In Vivo)

KRN5500 (4 mg/kg; 腹腔注射; 每天 1 次，共 5 天) 显示抗肿瘤活性，导致一些小鼠肿瘤和人肿瘤异种抑制模型中的肿瘤重量下降[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model with murine tumors and human tumor xenografts[2]
Dosage: 4 mg/kg
Administration: Intraperitoneal injection; once daily for 5 days
Result: Prolonged the survival of P388 leukemia- and B16 melanoma-bearing mice but lacked marginally effective on colon adenocarcinoma.
Decreased tumor weight in 10 human stomach, 14 colon and 2 esophageal cancers.
Clinical Trial
分子量

589.68

Formula

C28H43N7O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRN5500 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRN5500151276-95-8NSC 650426KRN 5500KRN-5500NSC650426NSC-650426AntibioticBcl-2 FamilyApoptosisInhibitorinhibitorinhibit

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