2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. KUL-7211

KUL 7211 是一种选择性β-肾上腺素受体激动剂。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

KUL-7211 Chemical Structure

KUL-7211 Chemical Structure

CAS No. : 220129-58-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Other Forms of KUL-7211:

KUL-7211 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

KUL 7211 is a selective β-adrenoceptor agonist.

IC50 & Target

β-adrenoceptor[1]
体外研究
(In Vitro)

KUL 7211 (KUL-7211) is a new β-adrenoceptor agonist in vitro. In rat isolated organs, its selectivities, for inhibition of spontaneous uterine contraction (mediated via β2-adrenergic stimulation) and inhibition of colonic contraction (via β3-adrenergic stimulation) versus increase in atrial rate (via β1-adrenergic stimulation), are 56.3 and 242.2, respectively. KUL 7211 relaxes 80 mM KCl induced tonic contractions in both rabbit (pD2 value: 5.86±0.13, whose ureteral relaxation is mediated via β2-adrenergic stimulation) and canine (pD2 value: 6.52±0.16, via β3-adrenergic stimulation) isolated ureters in a concentration-dependent manner. These KUL 7211-induced relaxing effects are antagonized by ICI-118,551 (selective β2-adrenoceptor antagonist, pKB value: 8.91±0.24) in the rabbit ureter and by bupranolol (non-selective β-adernoceptor antagonist, pKB value: 6.85±0.12) in the canine ureter. KUL 7211 also reduces the spontaneous rhythmic contraction in a canine ureteral spiral preparation in a concentration-dependent manner, the pD2 value being 6.83±0.20. These data clearly demonstrate that KUL 7211 selectively stimulates both ureteral β2- and β3-adrenoceptors and potently relaxes ureteral smooth muscle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KUL-7211 相关抗体:
分子量

345.39

Formula

C19H23NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Kinase Assay
[1]

KUL 7211 (KUL-7211) is dissolved in distilled water with an equivalent molarity of HCl[1].
Experiments are carried out using rat isolated atria, uterus, and proximal colon. Rats are stunned and then killed by rapid exsanguination. Each organ is rapidly removed and suspended in a 10 or 20 mL organ bath. The bath solution is Krebs solution (118.1 mM NaCl, 4.7 mM KCl, 2.5 mM CaCl2, 1.2 mM MgSO4• 7H2O, 25.0 mM NaHCO3, 1.2 mM KH2PO4, 11.1 mM glucose) in the atria and colon experiments and Locke-Ringer solution (154 mM NaCl, 5.6 mM KCl, 2.6 mM CaCl2, 2.1 mM MgCl2, 6.0 mM NaHCO3, 2.8 mM glucose) in the uterus experiment. Each is continuously gassed with a mixture of 95% oxygen and 5% carbon dioxide at 37°C. The bath solutions contain 1 μM phentolamine, 0.5μM desipramine, and 3 0μ M hydrocortisone to block α-adrenoceptors and neuronal and extraneuronal catecholamine uptake, respectively. Spontaneous contractions are measured isometrically by means of a force-transducer and measuring system (TB-611T, AP-601G, and RPM-6004 or model 45196A, model 1829, and model 7903) connected to a thermowriting rectigraph. An initial resting tension of 5 mN is placed on each organ, and it is allowed to equilibrate for 1 h. Each preparation is exposed to only one drug[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

KUL-7211 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KUL-7211220129-58-8KUL7211KUL 7211Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
KUL-7211
目录号：
HY-19673
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z