1. 天然产物
  2. 疾病研究领域 植物 黄酮类 酚类
  3. 癌症 其他科 二氢黄酮 多酚类
  4. Kuwanon E

Kuwanon E  (Synonyms: 桑皮酮 E)

目录号: HY-N3514 纯度: ≥96.0%
COA 产品使用指南

Kuwanon E 是从桑树中分到的黄酮类化合物,对人单核细胞白血病细胞系具有细胞毒性,并降低 IL-1β 的水平。

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Kuwanon E Chemical Structure

Kuwanon E Chemical Structure

CAS No. : 68401-05-8

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规格 价格 是否有货 数量
1 mg ¥2500
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β[1].

IC50 & Target

Kuwanon E shows cytotoxic activity against THP-1 human monocytic leukemic cell line, with an IC50 of 4.0±0.08 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BJ EC50
> 10 μM
Compound: 13
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
CCRF-CEM EC50
> 10 μM
Compound: 13
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
HeLa EC50
> 10 μM
Compound: 13
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
MCF7 EC50
> 10 μM
Compound: 13
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
RPMI-8226 EC50
> 10 μM
Compound: 13
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
THP-1 EC50
> 10 μM
Compound: 13
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
[PMID: 20192247]
THP-1 IC50
4 μM
Compound: 4
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
[PMID: 24901948]
U-266 EC50
> 10 μM
Compound: 13
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
分子量

424.49

Formula

C25H28O6

CAS 号
性状

固体

颜色

Off-white to light brown

中文名称

桑黄酮 E;桑酮 E;桑皮酮 E

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥96.0%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Kuwanon E
目录号:
HY-N3514
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