1. GPCR/G Protein Neuronal Signaling Apoptosis
  2. Dopamine Receptor Apoptosis
  3. L 741742

L 741742 是一种多巴胺受体 D4 (DRD4) 拮抗剂,可选择性地抑制胶质母细胞瘤 (GBM) 在体内和体外的生长,与 Temozolomide (TMZ) (HY-17364) 产生协同效应。L 741742 干扰效应物 PDGFRβ/ERK1/2 和 mTOR 信号传导。此外,L 741742 还干扰内溶酶体功能,破坏自噬-溶酶体降解通路,随后引发 G0/G1 细胞周期停滞和细胞凋亡 (Apoptosis)。L 741742 有望用于 GBM 和神经生成的研究。

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L 741742 Chemical Structure

L 741742 Chemical Structure

CAS No. : 156337-32-5

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生物活性

L 741742 is a dopamine receptor D4 (DRD4) antagonist that selectively inhibits glioblastomas (GBM) growth in vitro and in vivo, synergyed with Temozolomide (TMZ) (HY-17364). L 741742 disrupts in effectors PDGFRβ/ERK1/2 and mTOR signaling. Additionally, L 741742 disrupts endolysosmal function compromising the autophagy-lysosomal degradation pathway, followed by G0/G1 cell cycle arrest and Apoptosis. L 741742 is promising for research of GBM and neurogenesis[1].

分子量

380.91

Formula

C23H25ClN2O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
L 741742
目录号:
HY-101349
需求量: