L-870810

目录号: HY-12109: FAQs
Data Sheet 产品使用指南技术支持

L-870810 是一种有效的 HIV-1 IN 链转移抑制剂，具有抗病毒活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

L-870810 Chemical Structure

CAS No. : 410544-95-5

1. 客户无需承担相应的运输费用。

2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格		是否有货
50 mg		询价
100 mg		询价
250 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

L-870810 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 HIV 亚型特异性产品:

查看所有亚型

HIV HIV-1 HIV-2

生物活性
纯度 & 产品资料
参考文献

生物活性

L-870810 is a potent HIV-1 IN chain transfer inhibitor with antiviral activity^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
C8166	CC₅₀	123 μM Compound: L-870810	Cytotoxicity against human C8166 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human C8166 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 27810592]
C8166	CC₅₀	132 μM Compound: I-4, L-870810	Toxicity against human C8166 cells incubated for 72 hrs by MTT assay Toxicity against human C8166 cells incubated for 72 hrs by MTT assay	[PMID: 23098137]
C8166	EC₅₀	2.33 nM Compound: L-870810	Antiviral activity against HIV1 3B infected in human C8166 cells assessed as reduction in virus-induced cytopathic effect by MTT assay Antiviral activity against HIV1 3B infected in human C8166 cells assessed as reduction in virus-induced cytopathic effect by MTT assay	[PMID: 27810592]
C8166	EC₅₀	5 nM Compound: I-4, L-870810	Antiviral activity against HIV1 3B infected in human C8166 cells assessed as reduction in virus-induced cytopathogenicity measured after 3 days by syncytium reduction assay Antiviral activity against HIV1 3B infected in human C8166 cells assessed as reduction in virus-induced cytopathogenicity measured after 3 days by syncytium reduction assay	[PMID: 23098137]
HCT-116	IC₅₀	2 μM Compound: I-4, L-870810	Cytotoxicity against p53 expressing human HCT116 cells incubated for 72 hrs by MTT assay Cytotoxicity against p53 expressing human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 23098137]
HCT-116	IC₅₀	2 μM Compound: I-4, L-870810	Cytotoxicity against p53 deficient human HCT116 cells incubated for 72 hrs by MTT assay Cytotoxicity against p53 deficient human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 23098137]
Lymphocyte	CC₅₀	2100 nM Compound: L-870810	Cytotoxicity against human T lymphocyte cells infected with HIV1 BAL by XTT method in presence of 10% FBS Cytotoxicity against human T lymphocyte cells infected with HIV1 BAL by XTT method in presence of 10% FBS	[PMID: 19104010]
Lymphocyte	EC₅₀	3 nM Compound: L-870810	Antiviral activity against 0.001 MOI HIV1 BAL infected in human T lymphocyte cells by p24 antigen ELISA in presence of 10% FBS Antiviral activity against 0.001 MOI HIV1 BAL infected in human T lymphocyte cells by p24 antigen ELISA in presence of 10% FBS	[PMID: 19104010]
Lymphocyte	EC₅₀	60 nM Compound: L-870810	Antiviral activity against 0.001 MOI HIV1 BAL infected in human T lymphocyte cells by p24 antigen ELISA in presence of 10% FBS, HSA and alpha1-AGP Antiviral activity against 0.001 MOI HIV1 BAL infected in human T lymphocyte cells by p24 antigen ELISA in presence of 10% FBS, HSA and alpha1-AGP	[PMID: 19104010]
MCF7	IC₅₀	2 μM Compound: I-4, L-870810	Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 23098137]
MDA-MB-435	IC₅₀	6 μM Compound: I-4, L-870810	Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay	[PMID: 23098137]
MT2	EC₅₀	2 nM Compound: L-870810	Antiviral activity against HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 10% FBS Antiviral activity against HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 10% FBS	[PMID: 19104010]
MT2	EC₅₀	200 nM Compound: L-870810	Antiviral activity against 0.04 MOI HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 100% human serum Antiviral activity against 0.04 MOI HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 100% human serum	[PMID: 19104010]
MT2	CC₅₀	3000 nM Compound: L-870810	Cytotoxicity against human MT2 cells infected with HIV1 3B by three fold dilution method in presence of 10% FBS Cytotoxicity against human MT2 cells infected with HIV1 3B by three fold dilution method in presence of 10% FBS	[PMID: 19104010]
MT2	EC₅₀	41 nM Compound: L-870810	Antiviral activity against 0.01 MOI HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 100% human serum Antiviral activity against 0.01 MOI HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 100% human serum	[PMID: 19104010]
MT2	EC₅₀	43 nM Compound: L-870810	Antiviral activity against HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 10% FBS, HSA and alpha1-AGP Antiviral activity against HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 10% FBS, HSA and alpha1-AGP	[PMID: 19104010]
MT2	EC₅₀	96 nM Compound: L-870810	Antiviral activity against 0.02 MOI HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 100% human serum Antiviral activity against 0.02 MOI HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 100% human serum	[PMID: 19104010]
MT4	EC₅₀	0.004 μM Compound: L-870810	Antiviral activity against HIV 1 RIN harboring integrase gene infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV 1 RIN harboring integrase gene infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 18378713]
MT4	EC₅₀	0.004 μM Compound: L-870810	Antiviral activity against HIV 1 NL4.3 harboring integrase L74M mutant infected in human MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV 1 NL4.3 harboring integrase L74M mutant infected in human MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 18378713]
MT4	EC₅₀	0.0047 μM Compound: L-870810	Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction of virus-induced cytopathogenicity by MTT assay Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction of virus-induced cytopathogenicity by MTT assay	[PMID: 18351727]
MT4	EC₅₀	0.005 μM Compound: L-870810	Antiviral activity against HIV 1 3B infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV 1 3B infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 18378713]
MT4	EC₅₀	0.007 μM Compound: L-870810	Antiviral activity against HIV 1 NL4.3 integrase S230N mutant infected in human MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV 1 NL4.3 integrase S230N mutant infected in human MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 18378713]
MT4	EC₅₀	0.018 μM Compound: L-870810	Antiviral activity against HIV 1 RIN harboring integrase gene infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay after 20 passages selected in presence of compound Antiviral activity against HIV 1 RIN harboring integrase gene infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay after 20 passages selected in presence of compound	[PMID: 18378713]
MT4	EC₅₀	0.064 μM Compound: L-870810	Antiviral activity against HIV 1 RIN HIV 1 RIN harboring integrase gene infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay after 40 passages selected in presence of compound Antiviral activity against HIV 1 RIN HIV 1 RIN harboring integrase gene infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay after 40 passages selected in presence of compound	[PMID: 18378713]
MT4	EC₅₀	0.073 μM Compound: L-870810	Antiviral activity against HIV 1 NL4.3 integrase E92Q mutant infected in human MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV 1 NL4.3 integrase E92Q mutant infected in human MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 18378713]
MT4	EC₅₀	0.11 μM Compound: L-870810	Antiviral activity against HIV 1 3B harboring integrase E92Q S230N double mutant infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay selected after 20 passages in presence of compound Antiviral activity against HIV 1 3B harboring integrase E92Q S230N double mutant infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay selected after 20 passages in presence of compound	[PMID: 18378713]
MT4	EC₅₀	0.17 μM Compound: L-870810	Antiviral activity against HIV 1 3B harboring integrase L34M mutant infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay selected after 40 passages in presence of compound Antiviral activity against HIV 1 3B harboring integrase L34M mutant infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay selected after 40 passages in presence of compound	[PMID: 18378713]
MT4	EC₅₀	0.19 μM Compound: L-870810	Antiviral activity against HIV 1 RIN HIV 1 RIN harboring integrase gene infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay after 60 passages selected in presence of compound Antiviral activity against HIV 1 RIN HIV 1 RIN harboring integrase gene infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay after 60 passages selected in presence of compound	[PMID: 18378713]
MT4	EC₅₀	0.55 μM Compound: L-870810	Antiviral activity against HIV 1 3B harboring integrase E92Q, S230N and L34M triple mutant infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay selected after 60 passages in presence of compound Antiviral activity against HIV 1 3B harboring integrase E92Q, S230N and L34M triple mutant infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay selected after 60 passages in presence of compound	[PMID: 18378713]
MT4	IC₅₀	1.1 μM Compound: L-870810	Antiviral activity against HIV 1 3B infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay selected after 50 passages in presence of compound Antiviral activity against HIV 1 3B infected in MT-4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay selected after 50 passages in presence of compound	[PMID: 18378713]
MT4	CC₅₀	1600 nM Compound: L-870810	Cytotoxicity against human MT4 cells infected with HIV1 3B by three fold dilution method in presence of 10% FBS Cytotoxicity against human MT4 cells infected with HIV1 3B by three fold dilution method in presence of 10% FBS	[PMID: 19104010]
MT4	CC₅₀	2.2 μM Compound: L-870810	Cytotoxicity against human MT4 cells by MTT method Cytotoxicity against human MT4 cells by MTT method	[PMID: 18351727]
MT4	CC₅₀	2.25 μM Compound: L-870810	Cytotoxicity against human MT4 cells by MTT assay Cytotoxicity against human MT4 cells by MTT assay	[PMID: 18541726]
MT4	EC₅₀	4 nM Compound: L-870810	Antiviral activity against HIV1 3B infected in human MT-4 cells by two fold dilution method in presence of 10% FBS Antiviral activity against HIV1 3B infected in human MT-4 cells by two fold dilution method in presence of 10% FBS	[PMID: 19104010]
SK-N-MC	IC₅₀	28000 nM Compound: 5, L-870810	Inhibition of CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production after 1 hr Inhibition of CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production after 1 hr	[PMID: 21982500]
SUP-T1	EC₅₀	> 1000 nM Compound: L-870810	Antiviral activity against HIV1 infected in SupT1 cells assessed as accumulation of late RT products after 12 hrs Antiviral activity against HIV1 infected in SupT1 cells assessed as accumulation of late RT products after 12 hrs	[PMID: 19104010]
SUP-T1	EC₅₀	1.3 nM Compound: L-870810	Antiviral activity against HIV1 infected in SupT1 cells assessed as accumulation of integrated junction products after 48 hrs by Alu-PCR assay Antiviral activity against HIV1 infected in SupT1 cells assessed as accumulation of integrated junction products after 48 hrs by Alu-PCR assay	[PMID: 19104010]

分子量

430.45

Formula

C₂₀H₁₉FN₄O₄S

CAS 号

410544-95-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Zhang FH, et al. Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction. Eur J Med Chem. 2017 Jan 5;125:1051-1063. [Content Brief]

L-870810 相关分类

Infection

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-870810410544-95-5L870810L 870810HIVHuman immunodeficiency virusHIV-1 IN Chain Transfer InhibitorInhibitorinhibitorinhibit

您最近查看的产品:

产品名称：

* 需求量：

* 客户姓名：

* Email：

* 电话：

* 公司或机构名称：

留言给我们：

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

产品名称：			* Lot #：
* 客户姓名：			* Email：
电话：			* 部门：
* 公司或机构名称：
留言给我们：

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

L-870810

Customer Review

L-870810 相关抗体

L-870810 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 HIV 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

L-870810 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

Request for HNMR Report

Request for HNMR Report

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z