2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. NO Synthase Endogenous Metabolite
  4. L-NMMA citrate

L-NMMA citrate  (Synonyms: Methylarginine citrate; Tilarginine citrate)

目录号: HY-18732B
产品使用指南

摩尔计算器

L-NMMA citrate 竞争性地拮抗 L-精氨酸，从而抑制一氧化氮 (NO) 的产生。L-NMMA 在实验环境中用作一氧化氮合酶 (NO synthase) 拮抗剂。

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L-NMMA citrate Chemical Structure

L-NMMA citrate Chemical Structure

CAS No. : 209913-88-2

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L-NMMA citrate 的其他形式现货产品:

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L-NMMA citrate 相关抗体

Top Publications Citing Use of Products

    L-NMMA citrate purchased from MCE. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173.  [Abstract]

    L-NMMA acetate (200 μM; 48 h) leads to elevating ammonia and inhibiting CD8+ TM cell induction, in parallel with the inhibition of NO production.

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    nNOS iNOS eNOS

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    L-NMMA citrate competitively antagonizes L-arginine, and thus inhibits production of nitric oxide (NO). L-NMMA is utilized as NO synthase antagonist in experimental settings[1].

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    RAW264.7 IC50
    22.7 μM
    Compound: L-NMMA
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS stimulation and measured after 20 hrs by Griess reagent based assay
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells preincubated for 15 mins followed by LPS stimulation and measured after 20 hrs by Griess reagent based assay
    		[PMID: 36746775]
    RAW264.7 IC50
    25.1 μM
    Compound: L-NMMA
    Cancer chemopreventive activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by Griess reagent assay
    Cancer chemopreventive activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by Griess reagent assay
    		[PMID: 23316950]
    RAW264.7 IC50
    25.1 μM
    Compound: N-monomethyl-L-arginine citrate
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide overproduction pretreated with LPS for 24 hrs followed by overnight incubation with compound by Griess assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide overproduction pretreated with LPS for 24 hrs followed by overnight incubation with compound by Griess assay
    		[PMID: 31411887]
    RAW264.7 IC50
    25.1 μM
    Compound: L-NMMA
    Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
    Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
    		[PMID: 22850207]
    RAW264.7 IC50
    25.1 μM
    Compound: L-NMMA
    Cytotoxicity against mouse RAW264.7 cells assessed as cell survival by SRB assay
    Cytotoxicity against mouse RAW264.7 cells assessed as cell survival by SRB assay
    		[PMID: 23316950]
    RAW264.7 IC50
    32 μM
    Compound: L-NMMA
    Inhibition of iNOS-mediated NO production in mouse RAW264.7 cells by Griess assay
    Inhibition of iNOS-mediated NO production in mouse RAW264.7 cells by Griess assay
    		[PMID: 23994869]
    分子量

    380.35

    Formula

    C13H24N4O9
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    L-NMMA citrate 相关分类

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-NMMA209913-88-2MethylarginineTilarginineNO SynthaseEndogenous MetaboliteNitric oxide synthasesNOSCompetitiveNONO synthaseInhibitorinhibitorinhibit

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