2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Lactandrate

Lactandrate 是一种 D-高氮杂-雄甾酮烷化剂。Lactandrate 可以与雌激素受体-α (ERα) 的配体结合域 (LBD) 发生相互作用。Lactandrate 对乳腺癌细胞具有生长抑制作用，GI50 值在 5-65 μM 之间。Lactandrate 在小鼠乳腺肿瘤 (MXT 和 CD8F1) 以及人类异种移植 MX-1 中具有抗肿瘤活性。

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Lactandrate Chemical Structure

Lactandrate Chemical Structure

CAS No. : 43000-65-3

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Lactandrate 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Hs 766 IC50
> 100 μM
Compound: 104
Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay
Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay
[PMID: 29649739]
MCF7 GI50
5 μM
Compound: 104
Growth inhibition of human MCF7 cells after 48 h by MTT assay
Growth inhibition of human MCF7 cells after 48 h by MTT assay
[PMID: 29649739]
MIA PaCa-2 IC50
> 100 μM
Compound: 104
Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay
Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay
[PMID: 29649739]
PANC-1 IC50
> 100 μM
Compound: 104
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay
Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay
[PMID: 29649739]
T47D GI50
5 μM
Compound: 104
Growth inhibition of human T47D cells after 48 h by MTT assay
Growth inhibition of human T47D cells after 48 h by MTT assay
[PMID: 29649739]
分子量

563.60

Formula

C31H44Cl2N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lactandrate 相关分类

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  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lactandrate43000-65-3Estrogen Receptor/ERRInhibitorinhibitorinhibit

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