2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Lavoltidine

Lavoltidine  (Synonyms: Loxtidine; AH-234844)

目录号: HY-121450
产品使用指南

摩尔计算器

Lavoltidine (Loxtidine) 是一种具有口服活性的，不可逆且高效的组胺 H2 受体拮抗剂。Lavoltidine 强烈抑制胃酸分泌，并诱发高胃泌素血症。

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Lavoltidine Chemical Structure

Lavoltidine Chemical Structure

CAS No. : 76956-02-0

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Lavoltidine 相关抗体

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia[1].

IC50 & Target

H2 Receptor

 

体内研究
(In Vivo)

Lavoltidine (Loxtidine; 0.5 g/L; orally (drinking water); changed weekly; for 3 months) shows partial suppression of both gastric acid secretion and progression to neoplasia. Lavoltidine inhibits gastric atrophy, hyperplasia, and dysplasia in H felis-infected INS-GAS mice[1].
Lavoltidine treatment for 6 months inhibits gastric tumors in H felis-infected INS-GAS mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis[1]
Dosage: 0.5 g/L
Administration: Orally (drinking water); changed weekly; for 3 months
Result: Showed partial suppression of both gastric acid secretion and progression to neoplasia.
Clinical Trial
分子量

359.47

Formula

C19H29N5O2
CAS 号
中文名称

拉伏替丁
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lavoltidine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lavoltidine76956-02-0Loxtidine AH-234844拉伏替丁AH234844AH 234844AH-234844Histamine ReceptororallyirreversiblegastricacidsecretionhypergastrinemiatumorsHfelisInhibitorinhibitorinhibit

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