2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. LBA-3

LBA-3 是口服有效的钠偶联柠檬酸转运蛋白 SLC13A5 的选择性抑制剂，IC50 为 67 nM。LBA-3 可降低油酸和棕榈酸 (OPA) 刺激的 AML12 细胞、PCN 刺激的原代小鼠肝细胞以及小鼠模型中的甘油三酯和总胆固醇水平，且未检测到毒性。LBA-3 具有血脑屏障通透性。

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LBA-3 Chemical Structure

LBA-3 Chemical Structure

CAS No. : 2918263-09-7

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LBA-3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable[1].

体内研究
(In Vivo)

LBA-3 (50 mg/kg，口服，单剂量) 在 Sprague Dawley 大鼠中表现的药代动力学特征为血浆峰浓度 Cmax 为 288262.00 μg/L，AUC 为 704570.43 h/μg –1·L，口服生物利用度为 48.67%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

314.33

Formula

C18H18O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LBA-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LBA-32918263-09-7LBA3LBA 3Sodium ChannelNa channelsNa+ channelshyperlipidemiaAML12sprague Dawley ratsC57BL/6J miceInhibitorinhibitorinhibit

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