2. Apoptosis
  3. TNF Receptor
  4. Lenercept

Lenercept  (Synonyms: p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1)

目录号: HY-P99692

摩尔计算器

Lenercept (Ro 45-2081) 是一种重组融合蛋白，由可溶性 TNF-receptor (p55) 组成，连接到人 IgG1 的 Fc 部分。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CAS No. : 156679-34-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

Lenercept 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble TNF-receptor (p55) linked to the Fc portion of human IgG1[1].

种属

Human
IC50 & Target

TNFR[1]
体外研究
(In Vitro)

Lenercept (TNFR-IgG) 在放线菌素 D (HY-17559) 处理的小鼠 L-M 细胞中阻断 TNF-α 和 TNF-β 的细胞溶解作用，IC50 分别为 0.5 μg/mL 和 1.5 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lenercept 相关抗体:
体内研究
(In Vivo)

Lenercept (Ro 45-2081) 抑制 Sephadex 诱导的大鼠肺损伤[1]。
Lenercept (TNFR-IgG; 0.8-20 μg/mouse; i.v.; once) 当内毒素激发之前或之后不久给药时，可以预防或显著延迟内毒素诱导的小鼠致死率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 1 and 3 mg/kg
Administration: Intraperitoneal injection, 1 h before administration of Sephadex for the 24 h study or 1 h before and at 24 and 48 h after Sephadex for the 72 h study
Result: Inhibited the neutrophilia at 24 h after Sephadex. At 72 h after Sephadex, significantly reduced the neutrophil influx into bronchoalveolar lavage fluid (BALF) but had no inhibitory effect on eosinophil number.
Animal Model: 6- to 8-week-old female BALB/c mice, septic shock model[2]
Dosage: 0.8, 4 or 20 μg/mouse
Administration: IV, single dose
Result: Injection 0.5 h prior to Salmonella abortus-derived endotoxin (LD100 dose) administration prevented lethality at a dose of 20 μg per mouse and provided partial protection at lower doses. Injection of 10 μg per mouse provided significant protection 0.5 h before, 0.5 h after, or 1 h after endotoxin injection but little protection 2 h after endotoxin injection.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [TNFRSF1A (tumor necrosis factor receptor (TNFR)superfamilly member 1A, TNFAR, TNF-RI, TNF-R-I, p55, CD120a)]2-IGHG1 Fc (Fragment constant)
纯度 & 产品资料
参考文献

Lenercept 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenercept156679-34-4p55TNF-R:Ig Ro 45-2081 TNFR55-IgG1TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNF-αTNF-βL-M cellBALB/c miceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Lenercept
目录号：
HY-P99692
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z