2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Levalbuterol

Levalbuterol  (Synonyms: 左沙丁胺醇; (R)-Albuterol; (R)-Salbutamol; Levosalbutamol)

目录号: HY-B1675
产品使用指南 技术支持

Levalbuterol ((R)-Albuterol; (R)-Salbutamol) 是短效 β2-肾上腺素受体 (β2-adrenergic receptor) 激动剂和 Salbutamol 的活性 R 型对映异构体。Levalbuterol 是一种比 Salbutamol 更有效的支气管扩张试剂，可用于哮喘和慢性阻塞性肺疾病 (COPD) 的研究。

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Levalbuterol Chemical Structure

Levalbuterol Chemical Structure

CAS No. : 34391-04-3

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Levalbuterol 的其他形式现货产品:

Customer Review

Other Forms of Levalbuterol:

Levalbuterol 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T EC50
145 nM
Compound: salbutamol, albuterol
Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting
Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting
[PMID: 22182578]
HEK-293T EC50
275 nM
Compound: salbutamol, albuterol
Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM boric acid
Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM boric acid
[PMID: 22182578]
HEK-293T EC50
457 nM
Compound: salbutamol, albuterol
Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM phenylboronic acid
Agonist activity at recombinant human beta2 adrenoceptor expressed in HEK293T cells assessed as increase in IBMX-induced cAMP accumulation using [3H]-cAMP after 30 mins by liquid scintillation counting in presence of 100 uM phenylboronic acid
[PMID: 22182578]
体外研究
(In Vitro)

Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression in airway epithelial cells[1].
Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Levalbuterol 相关抗体:

RT-PCR[1]

Cell Line: Murine Club (MTCC) cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased 11β-HSD1 mRNA expression selectively.
体内研究
(In Vivo)

Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 female mice with a pulmonary allergic model[3]
Dosage: 1 mg/kg
Administration: Subcutaneous injection; 1 mg/kg; 14 days
Result: Decreased pulmonary inflammation after OVA sensitization.
Clinical Trial
分子量

239.31

Formula

C13H21NO3
CAS 号
中文名称

左沙丁胺醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Levalbuterol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levalbuterol34391-04-3(R)-Albuterol (R)-Salbutamol Levosalbutamol左沙丁胺醇Adrenergic ReceptorBeta Receptorasthmachronicobstructive pulmonaryCOPDbronchodilatorInhibitorinhibitorinhibit

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