2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Licopyranocoumarin

Licopyranocoumarin  (Synonyms: 甘草吡喃香豆素)

目录号: HY-119804
产品使用指南

摩尔计算器

Licopyranocoumarin 是一种异黄酮，具有 CYP3A4 抑制活性，IC50 为 32 μM。Licopyranocoumarin 具有有效的神经保护活性。

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Licopyranocoumarin Chemical Structure

Licopyranocoumarin Chemical Structure

CAS No. : 117038-80-9

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规格 价格 是否有货 数量
1 mg ￥7000
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

Licopyranocoumarin 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities[1].

IC50 & Target[2]

CYP3A4

32 μM (IC50)

体外研究
(In Vitro)

Licopyranocoumarin（0.3-3 μM；48 小时）显着阻断 MPP+ 诱导的神经元 PC12D 细胞死亡和线粒体膜电位消失，这是由 JNK[1] 介导的。
Licopyranocoumarin（0.3-3 μM；36 小时）通过抑制活性氧 (ROS) 的生成来抑制 MPP+ 诱导的 JNK 活化，从而抑制 MPP+ 诱导的神经元 PC12D 细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Licopyranocoumarin 相关抗体:

Cell Viability Assay[1]

Cell Line: PC12D cell
Concentration: 0.3 μM, 1 μM, 3 μM
Incubation Time: 48 hours
Result: Inhibited MPP+-induced cell death.

Western Blot Analysis[1]

Cell Line: PC12D cell
Concentration: 0.3 μM, 1 μM, 3 μM
Incubation Time: 36 hours
Result: Attenuated JNK activity induced by MPP+.
分子量

384.38

Formula

C21H20O7
CAS 号
中文名称

甘草吡喃香豆素
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Licopyranocoumarin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Licopyranocoumarin117038-80-9甘草吡喃香豆素Cytochrome P450CYPsisoflavonoidCYP3A4neuroprotective activitiesInhibitorinhibitorinhibit

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