2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. LLL3

LLL3 (CLT-005) 是一种 STAT3 抑制剂。LLL3 能够抑制 STAT3 的二聚化和磷酸化，从而阻止 STAT3 的核内转移，并且抑制 STAT3 依赖的基因表达，这些基因编码的蛋白包括 Bcl-xL 和 cyclin D1。此外，LLL3 还能通过 caspase 途径在人类乳腺癌和横纹肌肉瘤细胞中诱导细胞生长抑制和凋亡 (apoptosis)。LLL3 可用于 STAT3 持续激活类型癌症的研究。

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LLL3 Chemical Structure

LLL3 Chemical Structure

CAS No. : 63972-38-3

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LLL3 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LLL3 (CLT-005) is a STAT3 inhibitor. LLL3 inhibits dimerization and phosphorylation of STAT3, thereby preventing intraconuclear transfer of STAT3 and inhibits the expression of STAT3 dependent genes, which encode proteins such as Bcl-xL and cyclin D1. In addition, LLL3 can induce cell growth inhibition and apoptosis in human breast cancer and rhabdomyosarcoma cells via the caspase pathway. LLL3 can be used in the study of STAT3 persistent activation types of cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
11.5 μM
Compound: LLL3
Antiproliferative activity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
Antiproliferative activity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 24176397]
DU-145 IC50
16.2 μM
Compound: 1
Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTS assay
[PMID: 18006313]
HT-29 IC50
10.4 μM
Compound: LLL3
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 24176397]
LNCaP IC50
34.1 μM
Compound: 1
Antiproliferative activity against human LNCaP cells after 72 hrs by MTS assay
Antiproliferative activity against human LNCaP cells after 72 hrs by MTS assay
[PMID: 18006313]
MCF7 IC50
88.5 μM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 18006313]
PC-3 IC50
13.4 μM
Compound: 1
Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
[PMID: 18006313]
分子量

266.25

Formula

C16H10O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LLL3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LLL363972-38-3CLT-005LLL 3LLL-3CLT005CLT 005STATApoptosisSTAT3dimerizationphosphorylationinhibitorapoptosisInhibitorinhibit

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