2. Apoptosis
  3. Survivin Apoptosis
  4. LQZ-7F

LQZ-7F 是一种生存素二聚化 (survivin dimerization) 抑制剂，可在前列腺癌细胞中诱导自发细胞凋亡 (apoptosis) 并与多西紫杉醇协同作用。LQZ-7F 剂量依赖性地抑制 PC-3 和 C4-2 细胞的存活，IC50 分别为 2.99 和 2.47 µM。

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LQZ-7F Chemical Structure

LQZ-7F Chemical Structure

CAS No. : 354543-09-2

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规格 价格 是否有货 数量
1 mg ￥1600
In-stock
5 mg ￥4800
In-stock
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Customer Review

LQZ-7F 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LQZ-7F, a survivin dimerization inhibitor, induces spontaneous apoptosis and synergizes with Docetaxel in prostate cancer cells. LQZ-7F dose-dependently inhibits survival of both PC-3 and C4-2 cells with IC50s of 2.99 and 2.47 µM, respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.99 μM
Compound: 18, ZINC02092166
Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTS assay
Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 72 hrs by MTS assay
[PMID: 25985283]
HEK293 IC50
0.86 μM
Compound: 18, ZINC02092166
Inhibition of interaction of beta-catenin (unknown origin) transfected in Wnt-activated HEK293 cells/Tcf4 assessed as decrease in transactivation of canonical Wnt signaling by TOPflash luciferase reporter assay
Inhibition of interaction of beta-catenin (unknown origin) transfected in Wnt-activated HEK293 cells/Tcf4 assessed as decrease in transactivation of canonical Wnt signaling by TOPflash luciferase reporter assay
[PMID: 25985283]
HT-29 IC50
1.1 μM
Compound: 18, ZINC02092166
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTS assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 72 hrs by MTS assay
[PMID: 25985283]
SW480 IC50
0.71 μM
Compound: 18, ZINC02092166
Inhibition of beta-catenin/Tcf4 interaction in human SW480 cells assessed as decrease in transactivation of canonical Wnt signaling by TOPflash luciferase reporter assay
Inhibition of beta-catenin/Tcf4 interaction in human SW480 cells assessed as decrease in transactivation of canonical Wnt signaling by TOPflash luciferase reporter assay
[PMID: 25985283]
SW480 IC50
0.85 μM
Compound: 18, ZINC02092166
Cytotoxicity against human SW480 cells assessed as inhibition of cell growth after 72 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as inhibition of cell growth after 72 hrs by MTS assay
[PMID: 25985283]
体外研究
(In Vitro)

LQZ-7F could be hudrolyzed under acidic conditions[1].
LQZ-7F (2.5 μM, 72 hours) displays cytotoxicity towards human cancer cells (PC-3, C4-2) with the IC50s of 2.99 μM and 2.74 μM, respectively[1].
LQZ-7F effectively inhibits survival of all cancer cell lines with IC50 values ranging between 0.4 and 4.4 mM[2].
LQZ-7F (2 μM, 24 hours) disrupts microtubule structure and cause mitotic arrest in P3 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LQZ-7F 相关抗体:

Apoptosis Analysis[1]

Cell Line: PC3, HL-60 cells
Concentration: 0, 5, 10 μM
Incubation Time:
Result: Caused 54% to 69% apoptosis for PC3 and 66% to 98% apoptosis for HL-60 cells.

Cell Cytotoxicity Assay[1]

Cell Line: PC-3, DU145
Concentration: 10, 20 μM
Incubation Time: 72 hours
Result: Showed that the IC50 in human PC3 and DU145 cells was approximately 25 μM.
体内研究
(In Vivo)

LQZ-7F (i.p. injection; 25 mg/kg once every 3 days; 24 days) inhibits growth of xenograft tumor and may be due to its induction of surviving degradation in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4- to 6-week-old male NSG (NOD/SCID/IL-2Rg null) mice[2].
Dosage: 25 mg/kg
Administration: 24 days
Result: Inhibited growth of xenograft tumors by inhibiting surviving.
分子量

349.26

Formula

C14H7N9O3
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5 mg/mL (14.32 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8632 mL 14.3160 mL 28.6320 mL
5 mM 0.5726 mL 2.8632 mL 5.7264 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

LQZ-7F 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8632 mL 14.3160 mL 28.6320 mL 71.5799 mL
5 mM 0.5726 mL 2.8632 mL 5.7264 mL 14.3160 mL
10 mM 0.2863 mL 1.4316 mL 2.8632 mL 7.1580 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQZ-7F354543-09-2SurvivinApoptosissurvivin dimerizationapoptosisDocetaxelprostate cancer cellsPC-3 and C4-2Inhibitorinhibitorinhibit

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