2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. LS-106

LS-106 是具有口服活性强且有效的表皮生长因子受体 (EGFR) 抑制剂。LS-106 在体外和体内均表现出抗肿瘤活性。LS-106 抑制 EGFR19del/T790M/C797S 和 EGFRL858R/T790M/C797S 的激酶活性，IC50 值分别为 2.4 nmol/L 和 3.1 nmol/L，具有比 Osimertinib (HY-15772) 更强的抑制效果。LS-106 诱导细胞凋亡 (Apoptosis)，抑制携带 EGFR19del/T790M/C797S 的肿瘤细胞增殖，并在 C797S 突变异种移植模型中导致显著的肿瘤缩小。

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LS-106 Chemical Structure

LS-106 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

LS-106 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LS-106 is an orally active and potent inhibitor against epidermal growth factor receptor (EGFR) . LS-106 exhibits antitumor activities both in vitro and in vivo. LS-106 inhibits the kinase activities of EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S with IC50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, which is more potent than Osimertinib (HY-15772). LS-106 induces Apoptosis, suppresses cell proliferation of tumor cells harboring EGFR19del/T790M/C797S and leas to significant tumor regression in a C797S-mutant xenograft model[1].

IC50 & Target

EGFR19del/T790M/C797S

2.4 nM (IC50)

EGFRL858R/T790M/C797S

3.1 nM (IC50)

EGFRL858R/T790M

7.3 nM (IC50)

EGFR19del/T790M

74.1 nM (IC50)

EGFRwt

151.5 nM (IC50)

EGFR19del

402.9 nM (IC50)

分子量

548.84

Formula

C24H28BrClN5OP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LS-106 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LS-106LS106LS 106EGFRApoptosisEpidermal growth factor receptorErbB-1HER1orally activeantitumor activitiescell proliferationtumor regressionInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-164490
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