2. Epigenetics
  3. Histone Methyltransferase
  4. LSD1-IN-32

LSD1-IN-32 (compound 11e) 是一种有效的 LSD1 抑制剂，其 IC50 值为 0.99 µM。LSD1-IN-32 可抑制 RANKL 诱导的破骨细胞生成、骨吸收和 F-肌动蛋白带形成。LSD1-IN-32 具有研究骨质疏松症的潜力。

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LSD1-IN-32 Chemical Structure

LSD1-IN-32 Chemical Structure

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Other Forms of LSD1-IN-32:

LSD1-IN-32 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LSD1-IN-32 (compound 11e) is a potent LSD1 inhibitor with an IC50 value of 0.99 µM. LSD1-IN-32 inhibits RANKL-induced osteoclastogenesis, bone resorption and F-actin belt formation. LSD1-IN-32 has the potential for the research of osteoporosis[1].

IC50 & Target

IC50: 0.99 µM (LSD1)[1]
体外研究
(In Vitro)

LSD1-IN-32 (compound 11e) (1.25, 2.5, 5 µM) 以剂量依赖性方式增加破骨细胞生成过程中的甲基化水平[1]。
LSD1-IN-32 (0.25, 0.5, 1, 2, 4 µM) 抑制 RANKL 诱导的破骨细胞生成、骨吸收和 F-肌动蛋白带形成[1]。
LSD1-IN-32 (2 µM; 0, 1, 2, 4 days) 降低 RANKL 诱导的 Acp5、Nfatc1、Oscar、Dc-stamp、Atp6v0d2 和 Ctsk 基因的 mRNA 表达水平[1]。
LSD1-IN-32 (0.5, 1, 2, 4 µM) 可抑制 RANKL 诱导的破骨细胞生成中 p-LSD1、p-IκB 和 p-NFκB 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1-IN-32 相关抗体:

RT-PCR[1]

Cell Line: osteoclasts
Concentration: 2 µM
Incubation Time: 0, 1, 2, 4 days
Result: Reduced the relative mRNA expression levels of those genes (Acp5, Nfatc1, Oscar, Dc-stamp, Atp6v0d2, and Ctsk) induced by RANKL.

Western Blot Analysis[1]

Cell Line: osteoclasts
Concentration: 0.5, 1, 2, 4 µM
Incubation Time:
Result: Dose dependently inhibited the expressions of p-LSD1, p-IκB and p-NFκB in RANKL-induced osteoclastogenesis.
体内研究
(In Vivo)

LSD1-IN-32 (5, 10 mg/kg) 抑制了小鼠 OVX 诱导的破骨细胞性骨质流失[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-week-old C57BL/6 female mice (OVX (ovariectomy)-induced osteoporosis)[1]
Dosage: 5, 10 mg/kg
Administration: I.p.; daily for four weeks
Result: Significantly reduced the loss of the bone mass, reduced OVX-induced osteoclastic bone loss.
分子量

621.01

Formula

C36H56N2O3Si2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LSD1-IN-32 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-32Histone Methyltransferaseosteoporosisosteoclastsp-LSD1p-IκBp-NFκBbone lossInhibitorinhibitorinhibit

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目录号：
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