1. PROTAC Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  2. PROTACs HSP Apoptosis
  3. Lw13

Lw13 是一个靶向 Hsp90PROTAC,在 Siha 细胞中浓度为 0.05 μM 时降解效果最大。Lw13 诱导细胞凋亡 (apoptosis),在体外和体内均表现出强大的抗肿瘤活性(结构说明:(蓝色: Cereblon 配体(HY-A0003),黑色:连接体;粉红色:Hsp90 抑制剂 SNX-5422 (HY-10213))。

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Lw13 Chemical Structure

Lw13 Chemical Structure

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lw13 is a Hsp90-targeting PROTAC and achieves maximum degradation at a concentration of 0.05 μM in Siha cells. Lw13 induces cell apoptosis and exhibits potent anti-tumor activity both in vitro and in vivo(Sturcture Note:(Blue: Cereblon ligand (HY-A0003), Black: linker;Pink: Hsp90 inhibitor SNX-5422 (HY-10213))[1].

分子量

904.97

Formula

C46H55F3N8O8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Lw13
目录号:
HY-162589
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