2. Anti-infection
  3. Bacterial Antibiotic
  4. Lysostaphin

Lysostaphin  (Synonyms: 溶葡萄球菌素)

目录号: HY-P2329
COA 产品使用指南

摩尔计算器

Lysostaphin一种抗葡萄球菌剂。Lysostaphin 对甘氨酸内肽酶、内源性 β-N 乙酰化葡糖苷酶，以及 N 乙酰化胞壁酰丙氨酸酰胺酶有抑制活性。

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Lysostaphin Chemical Structure

Lysostaphin Chemical Structure

CAS No. : 9011-93-2

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1 mg ￥1100
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5 mg ￥3500
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10 mg ￥5500
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Lysostaphin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lysostaphin is an antistaphylococcal agent. Lysostaphin has activities of three enzymes namely, glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase[1].

体外研究
(In Vitro)

Lysostaphin (16 µg/mL, 0-260 分钟) 能通过水解 Staphylococcus aureus 的肽聚糖交联结构，削弱细胞壁的机械强度，并导致结构性损伤，从而发挥其抗菌作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lysostaphin 相关抗体:
体内研究
(In Vivo)

Lysostaphin (5 mg/kg，静脉注射，每日一次连续 3 天) 能够有效清除 CF-1 小鼠中的全身性金黄色葡萄球菌 (MSSA) 感染[2]。
Lysostaphin (50 mg/kg，静脉注射，单次给药) 可以有效清除肾脏、脾脏和肝脏中的金黄色葡萄球菌 (MSSA 和 MRSA) 感染，但效果并不优于多次低剂量给药[2]。
Lysostaphin (1 mg/kg，静脉注射，每日一次连续 3 天) 与 Oxacillin(HY-B0925A) 联合使用时，同样的抑菌效果可通过更低浓度 Lysostaphin 获得。 与 Vancomycin 联合使用时，低剂量 (1 mg/kg) 的 Lysostaphin (HY-B0671) 同样表现出对 MRSA 增强的疗效[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Systemic infection model in CF-1 mice induced by methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)[2]
Dosage: 1, 5, 25, 50 mg/kg
Administration: Intravenous injection (i.v.), single high-dose administration: 25 mg/kg or 50 mg/kg intravenous injection, single dose; Once daily administration: 1 or 5 mg/kg, once daily for 3 days.
Result: Cleared MSSA from the blood and organs of mice (5 mg/kg for 3 days).
Cleared MSSA and MRSA from the kidneys, spleen, and liver (A higher single dose of 50 mg/kg).
Improved effectiveness and allowed reduction of the lysostaphin dose to 1 mg/kg for MRSA infections (Combined with Oxacillin (HY-B0925A) or Vancomycin (HY-B0671)).
CAS 号
性状

固体

颜色

White to off-white

中文名称

溶葡萄球菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

COA (263 KB)

产品使用指南 (1538 KB)
参考文献

Lysostaphin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lysostaphin9011-93-2溶葡萄球菌素BacterialAntibioticCF-1 miceAntibacterial effectStaphylococcus aureus (MSSA)Staphylococcus aureus (MRSA)Inhibitorinhibitorinhibit

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