2. Immunology/Inflammation
  3. Toll-like Receptor (TLR) NO Synthase
  4. Macrophage-activating lipopeptide 2 TFA

Macrophage-activating lipopeptide 2 TFA  (Synonyms: MALP-2 TFA)

目录号: HY-P10586A 纯度: 98.60%
COA 产品使用指南

摩尔计算器

Macrophage-activating lipopeptide 2 TFA 是一种脂肽 Toll 样受体 TLR-2/TLR-6 激动剂。Macrophage-activating lipopeptide 2 可增强内皮一氧化氮合酶 (eNOS) 磷酸化和内皮细胞释放 NO，从而改善血管舒张。Macrophage-activating lipopeptide 2 可增强白细胞的内皮粘附，并改善接受实验性股动脉结扎 (FAL) 的高胆固醇血症 Apoe 缺陷小鼠后肢的灌注恢复和侧支生长。

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Custom Peptide Synthesis

Macrophage-activating lipopeptide 2 TFA Chemical Structure

Macrophage-activating lipopeptide 2 TFA Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥1350
In-stock
5 mg ￥3400
In-stock
10 mg ￥5500
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Macrophage-activating lipopeptide 2 TFA:

Macrophage-activating lipopeptide 2 TFA 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL)[1].
体外研究
(In Vitro)

Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) 可以促进主要内皮粘附分子及白细胞整合素受体的表达，从而增强白细胞的内皮粘附[1]。
Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) 可以促进内皮 MyEnd 细胞中蛋白激酶 B 和 eNOS 的磷酸化，从而促进 NO 释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Macrophage-activating lipopeptide 2 TFA 相关抗体:
体内研究
(In Vivo)

Macrophage-activating lipopeptide 2 (1 µg 溶于 125 µL PBS 中; 每天 1 次; 10 天; 静脉注射) 可以改善接受实验性股动脉结扎 (FAL) 的高胆固醇血症 Apoe 缺陷小鼠后肢的灌注恢复和侧支生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2135.56 (free base)

Formula

C99H167N19O30S.xC2HF3O2
性状

固体

颜色

White to off-white

Sequence

{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys
Sequence Shortening

{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 1.96 mg/mL (ultrasonic and adjust pH to 12 with 1 M NaOH)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Macrophage-activating lipopeptide 2 TFA 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Macrophage-activating lipopeptide 2MALP-2MALP2MALP 2Toll-like Receptor (TLR)NO SynthaseNitric oxide synthasesNOSToll-like receptorMyEnd cellendothelial adhesioncollateral growthInhibitorinhibitorinhibit

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