MANS peptide TFA 

MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis^[1].

MANS peptide TFA (0-100 μM, 12-24 h) 抑制肺癌细胞 CL1-0/F3、CL1-5、PC9 和 A549 的迁移和侵袭，而不对正常细胞造成毒性^[1]。
MANS peptide TFA (0-100 μM, 16 h) 抑制 MARCKS，PI3K 和 AKT 磷酸化，导致 Slug 信号下游和 E-钙粘蛋白表达水平的变化，防止细胞间粘附丧失，改变癌细胞的上皮-间质间转化 (EMT) 特征，从而减少肿瘤转移^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MANS peptide TFA (50 nmol/injection，腹腔注射，每 3 天一次，共 6 次) 可抑制 PC9 异种移植 NOD/SCID 小鼠模型中的肿瘤转移，但不影响肿瘤发生^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2498.83 (free acid)

C₁₁₁H₁₈₄N₃₀O₃₅._xC₂HF₃O₂

固体

White to off-white

{Myristic acid-Gly}-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-Gly-Glu-Ala-Ala-Ala-Glu-Arg-Pro-Gly-Glu-Ala-Ala-Val-Ala

{Myristic acid-Gly}-AQFSKTAAKGEAAAERPGEAAVA

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Chen CH, et al., A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10;33(28):3696-706.   [Content Brief]