2. Academic Validation
  3. Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum

Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum

  • J Nat Prod. 2000 Sep;63(9):1306-9. doi: 10.1021/np000029g.
C R Weiss 1,  S V Moideen,  S L Croft,  P J Houghton
Affiliations

Affiliation

  • 1 Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.
PMID: 11000047 DOI: 10.1021/np000029g
Abstract

Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC(50) values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.

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