2. Academic Validation
  3. Bioactive acridone alkaloids from Swinglea glutinosa

Bioactive acridone alkaloids from Swinglea glutinosa

  • J Nat Prod. 2001 Sep;64(9):1221-3. doi: 10.1021/np0005762.
B Weniger 1,  B H Um,  A Valentin,  A Estrada,  A Lobstein,  R Anton,  M Maillé,  M Sauvain
Affiliations

Affiliation

  • 1 UMR 7081, Faculté de Pharmacie, Université Louis Pasteur Strasbourg, BP 24, 67401 Illkirch Cedex, France. weninger@pharma.u-strasbg.fr
PMID: 11575960 DOI: 10.1021/np0005762
Abstract

A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known Acridone Alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated Alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.

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