2. Academic Validation
  3. Isolation and structure of palstatin from the Amazon tree Hymeneae palustris(1)

Isolation and structure of palstatin from the Amazon tree Hymeneae palustris(1)

  • J Nat Prod. 2003 Feb;66(2):259-62. doi: 10.1021/np020231e.
George R Pettit 1,  Yanhui Meng,  Clare A Stevenson,  Dennis L Doubek,  John C Knight,  Zbigniew Cichacz,  Robin K Pettit,  Jean-Charles Chapuis,  Jean M Schmidt
Affiliations

Affiliation

  • 1 Cancer Research Institute, Department of Chemistry, Arizona State University, Tempe, Arizona 85287-2404, USA. bpettit@asu.edu
PMID: 12608861 DOI: 10.1021/np020231e
Abstract

Bioassay (P388 lymphocytic leukemia cell line and human Cancer cell lines) guided separation of an extract prepared from the leaves of Hymenaea palustris Ducké led to the isolation of six Cancer cell growth inhibitory Flavonoids (1-6). The structures were elucidated by HRMS and 1D and 2D NMR spectral analysis. The new flavonolignan 1 designated palstatin proved to be a methoxy structural modification of 5'-methoxyhydnocarpin-D (2). Flavones 1-4 inhibited growth of the pathogenic bacteria Enterococcus faecalis and/or Neisseria gonorrhoeae.

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