2. Academic Validation
  3. Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists

Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists

  • Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. doi: 10.1016/j.bmcl.2007.06.030.
Jared B J Milbank 1,  Christopher S Knauer,  Corinne E Augelli-Szafran,  Annette T Sakkab-Tan,  Kristin K Lin,  Koji Yamagata,  Jennifer K Hoffman,  Nian Zhuang,  John Thomas,  Paul Galatsis,  John A Wendt,  John W Mickelson,  Roy D Schwarz,  Jack J Kinsora,  Susan M Lotarski,  Korana Stakich,  Kristen K Gillespie,  Wing W Lam,  Abdul E Mutlib
Affiliations

Affiliation

  • 1 Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. Jared.Milbank@Pfizer.com
PMID: 17590335 DOI: 10.1016/j.bmcl.2007.06.030
Abstract

Rational replacement of the alkyne linker of mGluR5 Antagonist MPEP gave 7-arylquinolines. SAR optimization gave an orally active compound with high affinity for the MPEP binding site.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z