2. Academic Validation
  3. Synthesis of curcumin mimics with multidrug resistance reversal activities

Synthesis of curcumin mimics with multidrug resistance reversal activities

  • Bioorg Med Chem. 2008 Apr 1;16(7):3608-15. doi: 10.1016/j.bmc.2008.02.012.
Yumi Um 1,  Sungsik Cho,  Ho Bum Woo,  Yong Kee Kim,  Hanna Kim,  Jungyeob Ham,  Su-Nam Kim,  Chan Mug Ahn,  Seokjoon Lee
Affiliations

Affiliation

  • 1 College of Medicine, Kwandong University, Gangneung 210-701, Republic of Korea.
PMID: 18295490 DOI: 10.1016/j.bmc.2008.02.012
Abstract

In order to discover novel multidrug resistance (MDR) reversal agents for efficient Cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6-19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells.

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