2. Academic Validation
  3. Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis

Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis

  • J Med Chem. 2009 Nov 26;52(22):7328-32. doi: 10.1021/jm901249g.
Jessica J Field 1,  A Jonathan Singh,  Arun Kanakkanthara,  Tu'ikolongahau Halafihi,  Peter T Northcote,  John H Miller
Affiliations

Affiliation

  • 1 Centre for Biodiscovery, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.
PMID: 19877653 DOI: 10.1021/jm901249g
Abstract

Zampanolide (1), a 20-membered Macrolide from a Tongan marine Sponge, stabilizes microtubules and blocks cells in G(2)/M of the cell cycle. Zampanolide is cytotoxic in the low nanomolar range and induces microtubule bundles in cells. It leads to tubulin assembly in cells and in purified tubulin preparations and is not a substrate for the P-glycoprotein drug efflux pump. Zampanolide, with only four stereogenic centers, may be amenable to large-scale synthetic preparation.

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