2. Academic Validation
  3. Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic

Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic

  • Org Lett. 2010 Jun 18;12(12):2814-7. doi: 10.1021/ol1009009.
Madan Kumar Kharel 1,  Pallab Pahari,  Hui Lian,  Jürgen Rohr
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.
PMID: 20486694 DOI: 10.1021/ol1009009
Abstract

A one-pot enzymatic total synthesis of angucycline Antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) Enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of Enzymes.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z