2. Academic Validation
  3. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

  • Eur J Med Chem. 2012 Sep;55:58-66. doi: 10.1016/j.ejmech.2012.07.001.
Ubaldina Galli 1,  Ornella Mesenzani,  Camilla Coppo,  Giovanni Sorba,  Pier Luigi Canonico,  Gian Cesare Tron,  Armando A Genazzani
Affiliations

Affiliation

  • 1 Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale A. Avogadro, Largo Donegani 2, 28100 Novara, Italy.
PMID: 22835719 DOI: 10.1016/j.ejmech.2012.07.001
Abstract

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for SIRT3 over SIRT1 and SIRT2.

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