2. Academic Validation
  3. Flavonoids as receptor tyrosine kinase FLT3 inhibitors

Flavonoids as receptor tyrosine kinase FLT3 inhibitors

  • Bioorg Med Chem Lett. 2013 Mar 15;23(6):1768-70. doi: 10.1016/j.bmcl.2013.01.049.
Young-Won Chin 1,  Jae Yang Kong,  Sun-Young Han
Affiliations

Affiliation

  • 1 College of Pharmacy, Dongguk University-Seoul, Goyang, Gyeonggi-do 410-820, South Korea.
PMID: 23411073 DOI: 10.1016/j.bmcl.2013.01.049
Abstract

The Fms-like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase, is involved in the proliferation, differentiation and Apoptosis of hematopoietic cells. FLT3 is highly overexpressed in acute myeloid leukemia (AML) of the majority of patients. Screening for Flavonoids including Flavones, flavanones, Flavonols, and Flavanonols disclosed that luteolin was potent FLT3 Enzyme inhibitor. Furthermore, luteolin suppressed cell proliferation in MV4;11 cells with constitutively activated FLT3.

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