2. Academic Validation
  3. Pharmacokinetic profile of spectinomycin in rats

Pharmacokinetic profile of spectinomycin in rats

  • Pharmazie. 2013 Aug;68(8):675-6.
D B Madhura 1,  R Lee,  B Meibohm
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, 881 Madison Ave, Suite 444, Memphis, TN 38163, USA.
PMID: 24020122
Abstract

Following intravenous (IV) administration, the pharmacokinetics of spectinomycin in rats was found to be on par with its profile in other mammalian species including humans with respect to its overall excretion and half-life at effective concentrations. This study, however, indicates that a small fraction of the spectinomycin dose is retained in peripheral tissues for a prolonged period of time at low concentrations.

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