2. Anti-infection
  3. Antibiotic Bacterial
  4. Spectinomycin sulfate hydrate

Spectinomycin sulfate hydrate 

目录号: HY-W928617
产品使用指南

摩尔计算器

Spectinomycin sulfate hydrate 是一种广谱抗生素，可以抑制多种革兰氏阳性和革兰氏阴性细菌的生长。Spectinomycin sulfate hydrate 通过特异靶向细菌核糖体，干扰蛋白质合成。Spectinomycin sulfate hydrate 也是 td 内含子 RNA 的非竞争性抑制剂，Ki 为 7.2 mM。

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Spectinomycin sulfate hydrate Chemical Structure

Spectinomycin sulfate hydrate Chemical Structure

CAS No. : 64058-48-6

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Spectinomycin sulfate hydrate 的其他形式现货产品:

Spectinomycin sulfate hydrate 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Spectinomycin sulfate hydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin sulfate hydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin sulfate hydrate is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM[1]-[5].

体外研究
(In Vitro)

Spectinomycin sulfate hydrate 选择性抑制细胞和大肠杆菌提取物中的蛋白质合成
Spectinomycin sulfate hydrate (50 μg/mL) 可快速且可逆地抑制大肠杆菌生长，并立即抑制氨基酸掺入[1]。
Spectinomycin sulfate hydrate (1 μg/mL or 3 μM) 可抑制由内源性信使 RNA 或 MS-2 噬菌体 RNA 指导的多肽合成，在大肠杆菌提取物中的最大抑制率为 70-80% [1]。
Spectinomycin sulfate hydrate 通过抑制结合来阻止肽基 tRNA 从 A 位易位到 P 位延伸因子 G 到核糖体[2]。
Spectinomycin sulfate hydrate 与 16S rRNA 中的残基 G1064 和 01192 特异性相互作用，并可能使其失活[2]。
Spectinomycin sulfate hydrate 表现出剪接抑制作用，并且依赖于 pH 变化和 Mg2+ 浓度，表明与内含子 RNA 存在静电相互作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Spectinomycin sulfate hydrate 相关抗体:
体内研究
(In Vivo)

Spectinomycin sulfate hydrate (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) 对健康小鸡表现出安全性[4]。
Spectinomycin sulfate hydrate (10 mg/kg; i.v.; single dose) 的主要消除途径是肾脏排泄，约 55% 以原形排泄到尿液中[5]。
药代动力学分析[5]

Parameter C0 (μg/mL) AUC0-∞ (μg•h/mL) Vd (L/kg) CL (L/h/kg) MRT (h) T1/2α (h) T1/2β (h) T1/2γ (h) fe CLrenal (L/h/kg) Eratio
Non atrioventricular analysis 44.3 16.8 0.756 0.602 0.757 / / / 0.553 0.359 1.00
Three-compartment model 37.8 15.7 0.747 0.649 1.11 / 0.237 0.754 19.5 / /

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Arbor Acres plus broiler chicks (15-day-old)[4]
Dosage: 20 mg/kg, 60 mg/kg, 100 mg/kg
Administration: Intramuscular injection (chest muscles); 9 days
Result: Showed biosecurity of 20 mg/kg by complete blood count, biochemical parameters, histopathological, clinical signs, body weight gain, and feed conversion ratio (FCR).
Resulted minor toxicity of 60 mg/kg.
分子量

502.49

Formula

C14H34N2O15S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Spectinomycin sulfate hydrate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spectinomycin sulfate64058-48-6AntibioticBacterialbiosecurityaminocyclitolbroad-spectrumgram-positivegram-negativeorganismbacterial ribosomeEscherichia coliamino acid incorporationMS-2 bacteriophagepeptidyl-tRNAelectrostatic interactionInhibitorinhibitorinhibit

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