2. Academic Validation
  3. Cytotoxic oxepinochromenone and flavonoids from the flower buds of Rosa rugosa

Cytotoxic oxepinochromenone and flavonoids from the flower buds of Rosa rugosa

  • J Nat Prod. 2013 Oct 25;76(10):1866-71. doi: 10.1021/np4004068.
Qiu-Fen Hu 1,  Bin Zhou,  Jian-Ming Huang,  Zhi-Yong Jiang,  Xiang-Zhong Huang,  Li-Ying Yang,  Xue-Mei Gao,  Guang-Yu Yang,  Chun-Tao Che
Affiliations

Affiliation

  • 1 Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
PMID: 24063567 DOI: 10.1021/np4004068
Abstract

A new oxepinochromenone, rugosachromenone A (1), seven new Flavonoids, rugosaflavonoids A-G (2-8), and 11 known compounds (9-19) were isolated from the flower buds of Rosa rugosa. Compound 1 is found from Nature for the first time. Compound 2 displayed cytotoxicity against NB4, SHSY5Y, and MCF7 cells with IC50 values of 2.2, 2.5, and 2.3 μM, respectively, and 3 was toxic to A549 and MCF7 cells with IC50 values of 1.2 and 2.8 μM, respectively.

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