2. Academic Validation
  3. Emergence of pyrido quinoxalines as new family of antimalarial agents

Emergence of pyrido quinoxalines as new family of antimalarial agents

  • Eur J Med Chem. 2014 Apr 22:77:280-7. doi: 10.1016/j.ejmech.2014.03.010.
A Chandra Shekhar 1,  P Shanthan Rao 2,  B Narsaiah 1,  Aparna Devi Allanki 3,  Puran Singh Sijwali 3
Affiliations

Affiliations

  • 1 Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
  • 2 Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. Electronic address: shanthanpp1954@gmail.com.
  • 3 CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
PMID: 24650715 DOI: 10.1016/j.ejmech.2014.03.010
Abstract

A series of novel N-alkyl dihydro pyrido quinoxaline derivatives were synthesized using Gould-Jacobs reaction and evaluated their antimalarial activity in vitro against chloroquine sensitive (3D7) and drug resistant (Dd2) strains of Plasmodium falciparum. Among the compounds tested, 10 compounds were more potent than their structural standard analog ciprofloxacin, including 2 derivatives 5e and 5h, which showed 3.3-7.4 times more potency than ciprofloxacin against both the Parasite strains. The results are encouraging and a lead molecule may emerge which is useful alone or in combination therapy.

Keywords

Antimalarial activity; Gould–Jacobs reaction; Plasmodium falciparum; Pyrido quinoxaline; Quinolones.

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