2. Academic Validation
  3. Ganoboninketals A-C, Antiplasmodial 3,4-seco-27-Norlanostane Triterpenes from Ganoderma boninense Pat

Ganoboninketals A-C, Antiplasmodial 3,4-seco-27-Norlanostane Triterpenes from Ganoderma boninense Pat

  • J Nat Prod. 2014 Aug 22;77(8):1847-52. doi: 10.1021/np5002863.
Ke Ma 1 2,  Jinwei Ren 1,  Junjie Han 1,  Li Bao 1,  Li Li 3,  Yijian Yao 1,  Chen Sun 4,  Bing Zhou 4,  Hongwei Liu 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, People's Republic of China.
  • 2 University of Chinese Academy of Sciences , Beijing, 100049, People's Republic of China.
  • 3 Department of Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, 100050, People's Republic of China.
  • 4 State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University , Beijing, 100084, People's Republic of China.
PMID: 25076059 DOI: 10.1021/np5002863
Abstract

Three new nortriterpenes, ganoboninketals A-C (1-3), featuring rearranged 3,4-seco-27-norlanostane skeletons and highly complex polycyclic systems were isolated from the medicinal mushroom Ganoderma boninense. The structures of the new metabolites were established by spectroscopic methods. The absolute configurations in 1-3 were assigned by electronic circular dichroism (ECD) calculations. Compounds 1-3 showed antiplasmodial activity against Plasmodium falciparum with IC50 values of 4.0, 7.9, and 1.7 μM, respectively. Compounds 1 and 3 also displayed weak cytotoxicity against A549 cell line with IC50 values of 47.6 and 35.8 μM, respectively. Compound 2 showed weak cytotoxicity toward HeLa cell line with an IC50 value of 65.5 μM. Compounds 1-3 also presented NO inhibitory activity in the LPS-induced macrophages with IC50 values of 98.3, 24.3, and 60.9 μM, respectively.

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