2. Academic Validation
  3. IFNA2: The prototypic human alpha interferon

IFNA2: The prototypic human alpha interferon

  • Gene. 2015 Aug 10;567(2):132-7. doi: 10.1016/j.gene.2015.04.087.
Franciane Paul 1,  Sandra Pellegrini 2,  Gilles Uzé 3
Affiliations

Affiliations

  • 1 CNRS UMR 5235, University Montpellier, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
  • 2 Institut Pasteur, 25 rue du Dr. Roux, 75015 Paris, France.
  • 3 CNRS UMR 5235, University Montpellier, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France. Electronic address: uze@univ-montp2.fr.
PMID: 25982860 DOI: 10.1016/j.gene.2015.04.087
Abstract

The human interferon α2 (IFNα2) was the first highly active IFN subtype to be cloned in the early eighties. It was also the first IFN and the first cytokine to be produced and commercialized by the pharmaceutical industry. Ipso facto it became the favorite IFNα subtype for academic researchers. For this fortunate reason IFNα2 has been at the origin of most discoveries related to the mechanism of action of type I interferons.

Keywords

Cytokine; Interferon α2; Type I interferon.

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