2. Academic Validation
  3. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells

Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells

  • Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3. doi: 10.1016/j.bmcl.2015.04.106.
Hiroaki Sasaki 1,  Yuki Kitoh 2,  Mariko Tsukada 2,  Kazuhiko Miki 2,  Kiyotaka Koyama 2,  Lia D Juliawaty 3,  Euis H Hakim 3,  Kunio Takahashi 2,  Kaoru Kinoshita 4
Affiliations

Affiliations

  • 1 School of Pharmacy, Shujitsu University, Nishigawara 1-6-1, Naka-ku, Okayama-shi, Okayama 703-8516, Japan.
  • 2 Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
  • 3 Natural Products Chemistry Research Group, Program Study of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.
  • 4 Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan. Electronic address: kaoru@my-pharm.ac.jp.
PMID: 26004578 DOI: 10.1016/j.bmcl.2015.04.106
Abstract

A major hallmark of Alzheimer's disease is the cerebral accumulation and resulting cytotoxicity of Amyloid-β peptides, particularly Aβ42. In this study, we used an MTT assay to investigate the inhibitory activity of biflavonoids 1-22 against Aβ42 cytotoxicity in PC-12 cell cultures. Cytoprotective effects were observed for the following amentoflavone type biflavonoids: podocarpusflavone B 8, isoginkgetin 10, sciadopitysin 13, and kayaflavone 15. These biflavonoids exhibited strong activity in tested compounds, with EC50 values of 5.18, 10.77, 9.84, and 5.29 μM, respectively. Cell viability tests of PC-12 cells revealed that biflavonoids 13 and 15 had stronger inhibitory activities than apigenin 23 and (-)-epigallocatechin gallate 24.

Keywords

Alzheimer’s disease; Amentoflavone; Amyloid-β; Biflavonoids; PC-12 cells.

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