2. Academic Validation
  3. ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice

ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice

  • Biochem Biophys Res Commun. 2015 Dec 25;468(4):877-82. doi: 10.1016/j.bbrc.2015.11.047.
Kazuaki Ohara 1,  Kaori Kusano 2,  Sayoko Kitao 2,  Takaaki Yanai 3,  Ryoji Takata 3,  Osamu Kanauchi 2
Affiliations

Affiliations

  • 1 Kirin Company, Limited, Research Laboratories for Health Science and Food Technologies, Research and Development Division, 1-13-5, Fukuura Kanazawa-ku, Yokohama 236-0004, Japan. Electronic address: Kazuaki_Ohara@kirin.co.jp.
  • 2 Kirin Company, Limited, Research Laboratories for Health Science and Food Technologies, Research and Development Division, 1-13-5, Fukuura Kanazawa-ku, Yokohama 236-0004, Japan.
  • 3 Mercian Corporation, New Product & Process Developments, 4-9-1 Johnan, Fujisawa, Kanagawa 251-0057, Japan.
PMID: 26596701 DOI: 10.1016/j.bbrc.2015.11.047
Abstract

Red wines are thought to be one of the major dietary sources of trans-resveratrol. The beneficial effects of t-resveratrol against metabolic disorders have been well characterized, however, red wines also contain various resveratrol derivatives whose health benefits have not been completely elucidated. In this report, we investigated ε-viniferin, a resveratrol dimer, which is present at comparable concentrations to t-resveratrol in red wines, and has higher anti-adipogenesis activity in 3T3-L1 cells. In addition, ε-viniferin was more effective than t-resveratrol in its anti-obesity and anti-inflammatory effects in high-fat diet fed mice. These results suggested ε-viniferin may be one of the active ingredients against metabolic disorders in red wines, in addition to t-resveratrol.

Keywords

Grape shoot extract; Obesity; Resveratrol; ε-Viniferin.

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