ε-​Viniferin  (Synonyms: epsilon-Viniferin)

ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with K_i values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity^[1][2][3].

ε-​Viniferin (1-15 μM，24-72 小时) 抑制 HOS、U2OS 和 A549 细胞的增殖^[3]。
ε-​Viniferin (20 μM，24 小时) 在 HOS、U2OS、A549 细胞中诱导 DNA 片段化和核浓缩^[3]。
ε-​Viniferin (10 μM，1 小时) 抑制 TGF-β1 诱导的 A549 细胞 EMT、侵袭和迁移，并逆转 TGF-β1 诱导的 ROS、MMP2、波形蛋白、Zeb1、Snail、p-SMAD2、p-SMAD3 和 ABCG2 表达 ^[4]。
ε-​Viniferin (10 μM，3 分钟) 抑制 fMLP (0.1 μM) 诱导的人中性粒细胞中超氧阴离子的产生，以及 fMLP 诱导的 ERK、Akt、Src 磷酸化或细胞内钙动员^[5]。
ε-​Viniferin (50 nM-10 μM，48 小时) 通过 SIRT3/FOXO3 途径保护细胞免受鱼藤酮 (HY-B1756) 诱导的 SH-SY5Y 细胞神经毒性^[6]。
ε-​Viniferin (1 μM，24 小时) 抑制鱼藤酮 Rotenone (HY-B1756) 诱导的 SH-SY5Y 细胞中线粒体去极化和氧化应激^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ε-​Viniferin (5 mg/kg，腹腔注射，每周 5 天，持续 4 周) 抑制 A549 细胞异种移植裸鼠模型中的肿瘤生长 (无肝肾损伤)，并抑制 A549 细胞肺转移小鼠模型中的肿瘤转移^[3][4]。
ε-​Viniferin (饮食中 0.2%，4 周) 可预防小鼠饮食诱发的肥胖^[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

454.47

C₂₈H₂₂O₆

62218-08-0

固体

Off-white to gray

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Piver B, et al. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci. 2003 Jul 18;73(9):1199-213.  [Content Brief]

  [2]. XAVIER VITRAC, et al. Determination of Stilbenes (δ-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, E-viniferin) in Brazilian Wines. J. Agric. Food Chem. 2005, 53, 5664−5669.

  [3]. Huang C, et al. ε-Viniferin and α-viniferin alone or in combination induced apoptosis and necrosis in osteosarcoma and non-small cell lung cancer cells. Food Chem Toxicol. 2021 Dec;158:112617.  [Content Brief]

  [4]. Chiou WC, et al. α-Viniferin and ε-Viniferin Inhibited TGF-β1-Induced Epithelial-Mesenchymal Transition, Migration and Invasion in Lung Cancer Cells through Downregulation of Vimentin Expression. Nutrients. 2022 May 30;14(11):2294.  [Content Brief]

  [5]. Liao HR, et al. The anti-inflammatory effect of ε-viniferin by specifically targeting formyl peptide receptor 1 on human neutrophils. Chem Biol Interact. 2021 Aug 25;345:109490.  [Content Brief]

  [6]. Zhang S, et al. Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation. Neural Regen Res. 2020 Nov;15(11):2143-2153.  [Content Brief]

  [7]. Ohara K, et al. ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice. Biochem Biophys Res Commun. 2015 Dec 25;468(4):877-82.  [Content Brief]