2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. ε-​Viniferin

ε-​Viniferin  (Synonyms: epsilon-Viniferin)

目录号: HY-N3841 纯度: ≥98.0%
COA 产品使用指南 技术支持

ε-Viniferin (epsilon-Viniferin) 可以从Vitis vinifera 提取得到，是一种 Resveratrol 的二聚体，可有效抑制 CYP 家族，Ki 值在0.5-20 μM 之间。ε-Viniferin 具有强大的抗氧化、抗炎、抗糖尿病和抗神经退行性疾病活性。

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ε-​Viniferin Chemical Structure

ε-​Viniferin Chemical Structure

CAS No. : 62218-08-0

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规格 价格 是否有货 数量
1 mg ￥3800
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Other Forms of ε-​Viniferin:

ε-​Viniferin 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity[1][2][3].

IC50 & Target

CYP2B6

3 μM (Ki, (BROD))

CYP1A2

5 μM (Ki, (EROD))

CYP3A4

10 μM (Ki, (TST))

CYP4A

15 μM (IC50, (LwOH))

CYP2E1

25 μM (IC50, (CHZ))

CYP2A6

60 μM (Ki, (COH))

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 CC50
54.7 μM
Compound: (+)-Epsilon-Viniferin
Cytotoxicity against human A549 cells assessed as reduction in cell viability by Alamar blue assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by Alamar blue assay
[PMID: 32652408]
BTI-TN-5B1-4 IC50
19.6 μM
Compound: Epsilon-Viniferin
Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate after 15 mins by resorufin dye-based spectrometric analysis
Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate after 15 mins by resorufin dye-based spectrometric analysis
[PMID: 30686752]
体外研究
(In Vitro)

ε-​Viniferin (1-15 μM，24-72 小时) 抑制 HOS、U2OS 和 A549 细胞的增殖[3]。
ε-​Viniferin (20 μM，24 小时) 在 HOS、U2OS、A549 细胞中诱导 DNA 片段化和核浓缩[3]。
ε-​Viniferin (10 μM，1 小时) 抑制 TGF-β1 诱导的 A549 细胞 EMT、侵袭和迁移，并逆转 TGF-β1 诱导的 ROS、MMP2、波形蛋白、Zeb1、Snail、p-SMAD2、p-SMAD3 和 ABCG2 表达 [4]。
ε-​Viniferin (10 μM，3 分钟) 抑制 fMLP (0.1 μM) 诱导的人中性粒细胞中超氧阴离子的产生，以及 fMLP 诱导的 ERK、Akt、Src 磷酸化或细胞内钙动员[5]。
ε-​Viniferin (50 nM-10 μM，48 小时) 通过 SIRT3/FOXO3 途径保护细胞免受鱼藤酮 (HY-B1756) 诱导的 SH-SY5Y 细胞神经毒性[6]。
ε-​Viniferin (1 μM，24 小时) 抑制鱼藤酮 Rotenone (HY-B1756) 诱导的 SH-SY5Y 细胞中线粒体去极化和氧化应激[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ε-​Viniferin 相关抗体:

Western Blot Analysis[4]

Cell Line: A549 cells
Concentration: 10 μM
Incubation Time: 1 h
Result: Inhibited TGF-β1-induced MMP2, vimentin, Zeb1, p-SMAD2, p-SMAD3, and ABCG2 expression.
体内研究
(In Vivo)

ε-​Viniferin (5 mg/kg，腹腔注射，每周 5 天，持续 4 周) 抑制 A549 细胞异种移植裸鼠模型中的肿瘤生长 (无肝肾损伤)，并抑制 A549 细胞肺转移小鼠模型中的肿瘤转移[3][4]。
ε-​Viniferin (饮食中 0.2%，4 周) 可预防小鼠饮食诱发的肥胖[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 cell xenograft nude mice model[3]
Dosage: 5 mg/kg
Administration: i.p., 5 days per week for 4 weeks
Result: Inhibited tumor weight and volume.
Induced apoptosis in tumor sections.
Decreased serum ALT, AST, bilirubin, and creatinine levels.
分子量

454.47

Formula

C28H22O6
CAS 号
性状

固体

颜色

Off-white to gray

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥98.0%

COA (273 KB)

产品使用指南 (1538 KB)
参考文献

ε-​Viniferin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ε-​Viniferin62218-08-0epsilon-ViniferinCytochrome P450CYPsantioxidantanti-inflammatoryanti-diabeticanti-neurodegenerativeInhibitorinhibitorinhibit

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