2. Academic Validation
  3. Bioactive phenols as potential neuroinflammation inhibitors from the leaves of Xanthoceras sorbifolia Bunge

Bioactive phenols as potential neuroinflammation inhibitors from the leaves of Xanthoceras sorbifolia Bunge

  • Bioorg Med Chem Lett. 2016 Oct 15;26(20):5018-5023. doi: 10.1016/j.bmcl.2016.08.094.
Ning Li 1,  Ying Wang 1,  Xuezheng Li 2,  Hong Zhang 1,  Di Zhou 1,  Wenli Wang 1,  Wei Li 3,  Xiangrong Zhang 3,  Xinyu Li 4,  Yue Hou 5,  Dali Meng 6
Affiliations

Affiliations

  • 1 School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.
  • 2 Department of Pharmacy, Affiliated Hospital of Yanbian University, Yanji 133000, China.
  • 3 School of Functional Food and Red Wine, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China.
  • 4 Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China. Electronic address: dlxinyuli1969@163.com.
  • 5 College of Life and Health Sciences, Department of Biochemistry and Molecular Biology, Northeastern University, Shenyang 110819, China. Electronic address: houyue@mail.neu.edu.cn.
  • 6 School of Traditional Chinese Materia Medica 49(#), Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China. Electronic address: mengdl@163.com.
PMID: 27623545 DOI: 10.1016/j.bmcl.2016.08.094
Abstract

Xanthoceras sorbifolia Bunge is a medicinal plant and also a valuable cash crop used for production of edible oil and biofuels in China. In our previous research, systematical phytochemical and bioactive profiles of different parts from X. sorbifolia have been obtained. Here we describe the effective Phenols from the leaves of X. sorbifolia, which could function as natural neuroinflammation inhibitors. As a result, 23 compounds were characterized as the Phenols from the leaves of X. sorbifolia by means of chromatographical methods and spectroscopic analysis. Among them, Flavonoids quercetin3-O-β-d-glucopyarnoside (IC50 13.39±1.27μM), catechin (IC50 9.52±2.18μM), and Phenylpropanoids syringaresinol-4-O-β-d-glucopyranoside (IC50 3.08±1.77μM), 4-O-β-d-glucopyranosyl-trans-p-coumaric acid (IC50 9.08±1.23μM) exhibited much stronger inhibiting effect on NO production than that of the positive control minocycline (IC50 37.04±2.09μM) in LPS-induced BV2 cells.

Keywords

LPS; Leaves; Microglia; Neurodegenerative diseases; Neuroinflammatory inhibitors; Xanthoceras sorbifolia Bunge.

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